한빛사논문
- 조회462
Hee Su Sohn1†, Jeong Won Choi2†, JooYeon Jhun2,3, Sung Pil Kwon1, Mungyo Jung1, Sangmin Yong4, Hyun Sik Na3,5, Jin-Hong Kim4, Mi-La Cho2,6*, Byung-Soo Kim1,7,8*
1School of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Republic of Korea.
2The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul 06591, Republic of Korea.
3Department of Biomedicine and Health Sciences, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.
4Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Republic of Korea.
5Lab of Translational Immuno Medicine, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
6Department of Medical Life-science, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.
7Institute of Chemical Processes, Insti-tute of Engineering Research, BioMAX, Seoul National University, Seoul 08826, Republic of Korea.
8Interdisciplinary Program for Bioengineering, Seoul National University, Seoul 08826, Republic of Korea.
*Corresponding authors: Mi-La Cho, Byung-Soo Kim
†These authors contributed equally to this work.
Abstract
Local inflammation in the joint is considered to contribute to osteoarthritis (OA) progression. Here, we describe an immunomodulating nanoparticle for OA treatment. Intradermal injection of lipid nanoparticles (LNPs) loaded with type II collagen (Col II) and rapamycin (LNP-Col II-R) into OA mice effectively induced Col II-specific anti-inflammatory regulatory T cells, substantially increased anti-inflammatory cytokine expression, and reduced inflammatory immune cells and proinflammatory cytokine expression in the joints. Consequently, LNP-Col II-R injection inhibited chondrocyte apoptosis and cartilage matrix degradation and relieved pain, while injection of LNPs loaded with a control peptide and rapamycin did not induce these events. Adoptive transfer of CD4+CD25+ T cells isolated from LNP-Col II-R-injected mice suggested that Tregs induced by LNP-Col II-R injection were likely responsible for the therapeutic effects. Collectively, this study suggests nanoparticle-mediated immunomodulation in the joint as a simple and effective treatment for OA.
논문정보
- Research article
- 2022년 11월 (BRIC 등록일 2022-12-01)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
댓글 작성 로그인
팝업 닫기관련 링크
관련분야 연구자보기
관련분야 논문보기
