한빛사논문
- 조회751
Georgios Theocharidis 1,12, Hyunwoo Yuk 2,10,12 , Heejung Roh2,12, Liu Wang 2,11,12, Ikram Mezghani1, Jingjing Wu 2,3, Antonios Kafanas4, Mauricio Contreras5, Brandon Sumpio1, Zhuqing Li1, Enya Wang1, Lihong Chen1, Chuan Fei Guo 3, Navin Jayaswal1, Xanthi-Leda Katopodi 6, Nikolaos Kalavros6, Christoph S. Nabzdyk 7, Ioannis S. Vlachos6,8, Aristidis Veves 1 and Xuanhe Zhao 2,9
1Joslin-Beth Israel Deaconess Foot Center and The Rongxiang Xu, MD, Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center,
Harvard Medical School, Boston, MA, USA.
2Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
3Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, China.
4Lincoln County Hospital, Northern Lincolnshire and Goole NHS Foundation Trust, Lincoln, Lincolnshire, UK.
5Division of Vascular Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
6Cancer Research Institute, HMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
7Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
8Broad Institute of MIT and Harvard, Cambridge, MA, USA.
9Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
10Present address: SanaHeal, Inc., Boston, MA, USA.
11Present address: CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui, China.
12These authors contributed equally: Georgios Theocharidis, Hyunwoo Yuk, Heejung Roh, Liu Wang.
These authors jointly supervised this work: Aristidis Veves, Xuanhe Zhao.
Corresponding authors: Correspondence to Hyunwoo Yuk, Aristidis Veves or Xuanhe Zhao.
Abstract
Diabetic foot ulcers and other chronic wounds with impaired healing can be treated with bioengineered skin or with growth factors. However, most patients do not benefit from these treatments. Here we report the development and preclinical therapeutic performance of a strain-programmed patch that rapidly and robustly adheres to diabetic wounds, and promotes wound closure and re-epithelialization. The patch consists of a dried adhesive layer of crosslinked polymer networks bound to a pre-stretched hydrophilic elastomer backing, and implements a hydration-based shape-memory mechanism to mechanically contract diabetic wounds in a programmable manner on the basis of analytical and finite-element modelling. In mouse and human skin, and in mini-pigs and humanized mice, the patch enhanced the healing of diabetic wounds by promoting faster re-epithelialization and angiogenesis, and the enrichment of fibroblast populations with a pro-regenerative phenotype. Strain-programmed patches might also be effective for the treatment of other forms of acute and chronic wounds.
논문정보
- Research article
- 2022년 10월 (BRIC 등록일 2022-11-25)
- 국외 연구진
- 바이오·의료융합 > 바이오소재
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