한빛사논문
- 조회302
Yuri Kim 1, Ramar Thangam 1 2, Jounghyun Yoo 3, Jeongyun Heo 3, Jung Yeon Park 4, Nayeon Kang 1, Sungkyu Lee 1, Jiwon Yoon 3, Kwang Rok Mun 5, Misun Kang 5, Sunhong Min 1, Seong Yeol Kim 1, Subin Son 6, Jihwan Kim 3 4, Hyunsik Hong 1, Gunhyu Bae 1, Kanghyeon Kim 1, Sanghyeok Lee 1, Letao Yang 7, Ja Yeon Lee 5, Jinjoo Kim 8, Steve Park 9, Dong-Hyun Kim 10, Ki-Bum Lee 7, Woo Young Jang 11, Bong Hoon Kim 12, Ramasamy Paulmurugan 13 14, Seung-Woo Cho 15 16, Hyun-Cheol Song 17 18, Seok Ju Kang 19, Wujin Sun 20, Yangzhi Zhu 8, Junmin Lee 21, Han-Jun Kim 8, Ho Seong Jang 5 22, Jong Seung Kim 6, Ali Khademhosseini 8, Yongju Kim 4, Sehoon Kim 3 4, Heemin Kang 1 23
1Department of Materials Science and Engineering, Korea University, Seoul, 02841, Republic of Korea.
2Institute for High Technology Materials and Devices, Korea University, Seoul, 02841, Republic of Korea.
3Chemical and Biological Integrative Research Center, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
4KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.
5Materials Architecturing Research Center, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
6Department of Chemistry, Korea University, Seoul, 02841, Republic of Korea.
7Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ, 08854, USA.
8Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90024, USA.
9Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
10Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
11Department of Orthopedic Surgery, Korea University Anam Hospital, Seoul, 02841, Republic of Korea.
12Daegu Gyeongbuk Institute of Science and Technology (DGIST), Department of Robotics and Mechatronics Engineering, Daegu, 42988, Republic of Korea.
13Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford University, Palo Alto, CA, 94304, USA.
14Department of Radiology, Canary Center at Stanford for Cancer Early Detection, Stanford University School of Medicine, Stanford University, Palo Alto, CA, 94304, USA.
15Department of Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.
16Center for Nanomedicine, Institute for Basic Science (IBS), Seoul, 03722, Republic of Korea.
17Electronic Materials Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
18KIST-SKKU Carbon-Neutral Research Center, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.
19School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.
20Department of Biological Systems Engineering, Virginia Tech, Blacksburg, VA, 24061, USA.
21Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
22Division of Nano & Information Technology, KIST School, Korea University of Science and Technology (UST), Seoul, 02792, Republic of Korea.
23College of Medicine, Korea University, Seoul, 02841, Republic of Korea.
CORRESPONDING AUTHORS: Sehoon Kim, Heemin Kang
Abstract
Dynamic manipulation of supramolecular self-assembled structures is achieved irreversibly or under non-physiological conditions, thereby limiting their biomedical, environmental, and catalysis applicability. In this study, microgels composed of azobenzene derivatives stacked via π-cation and π-π interactions are developed that are electrostatically stabilized with Arg-Gly-Asp (RGD)-bearing anionic polymers. Lateral swelling of RGD-bearing microgels occurs via cis-azobenzene formation mediated by near-infrared-light-upconverted ultraviolet light, which disrupts intermolecular interactions on the visible-light-absorbing upconversion-nanoparticle-coated materials. Real-time imaging and molecular dynamics simulations demonstrate the deswelling of RGD-bearing microgels via visible-light-mediated trans-azobenzene formation. Near-infrared light can induce in situ swelling of RGD-bearing microgels to increase RGD availability and trigger release of loaded interleukin-4, which facilitates the adhesion structure assembly linked with pro-regenerative polarization of host macrophages. In contrast, visible light can induce deswelling of RGD-bearing microgels to decrease RGD availability that suppresses macrophage adhesion that yields pro-inflammatory polarization. These microgels exhibit high stability and non-toxicity. Versatile use of ligands and protein delivery can offer cytocompatible and photoswitchable manipulability of diverse host cells.
논문정보
- Research article
- 2022년 10월 (BRIC 등록일 2022-11-18)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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