한빛사논문
- 조회275
Hee-Kyung Joh 1 2 3, Hyuktae Kwon 3 4 5, Ki Young Son 6, Jae Moon Yun 3 4, Su Hwan Cho 3 4, Kyungdo Han 7, Jin-Ho Park # 3 4 5, Belong Cho # 3 4 5
1Department of Medicine, Seoul National University College of Medicine, Seoul, Korea.
2Department of Family Medicine, Seoul National University Health Service Center, Seoul, Korea.
3Department of Family Medicine, Seoul National University Hospital, Seoul, Korea.
4Health Promotion Center, Seoul National University Hospital, Seoul, Korea.
5Department of Family Medicine, Seoul National University College of Medicine, Seoul, Korea.
6Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
7Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea.
#Contributed equally.
CORRESPONDING AUTHORS: Jin-Ho Park MD, MPH, PhD, Belong Cho MD, PhD
Abstract
Objective
To examine the associations between the allergic triad (asthma, allergic rhinitis, atopic dermatitis) and risk of dementia.
Methods
Participants comprised 6,785,948 adults aged ≥40 years who participated in a national health examination in 2009 without any history of dementia before baseline. From 2009 to 2017, we prospectively investigated the associations between physician-diagnosed allergic diseases and risk of incident dementia (all-cause, Alzheimer's disease [AD], vascular dementia [VaD]) ascertained using national health insurance claims data.
Results
During 8.1 years of follow-up, 260,705 dementia cases (195,739 AD, 32,789 VaD) were identified. Allergic diseases were positively associated with dementia risk. Compared with individuals without allergic diseases, multivariable hazard ratios (HRs) of all-cause dementia were 1.20 (95% confidence interval [CI] 1.19–1.22) in those with asthma, 1.10 (95% CI 1.09–1.12) with allergic rhinitis, 1.16 (95% CI 1.11–1.21) with atopic dermatitis, and 1.13 (95% CI 1.12–1.14) with any of these allergies. Similarly, individuals with any of the allergic triad had a higher risk of AD (HR 1.16, 95% CI 1.14–1.17) and VaD (HR 1.04; 95% CI 1.01–1.06) than those without any allergic disease. As the number of comorbid allergic diseases increased, the risk of dementia increased linearly (Ptrend ≤ 0.002). Compared with individuals without allergies, those with all three allergic diseases had substantially increased risk of all-cause dementia (HR 1.54, 95% CI 1.35–1.75), AD (HR 1.46; 95% CI 1.25–1.70), and VaD (HR 1.99, 95% CI 1.44–2.75).
Interpretation
Asthma, allergic rhinitis, and atopic dermatitis were significantly associated with increased risk of all-cause dementia and subtypes, with dose–effect relationships with the severity of allergic diseases. ANN NEUROL 2022
논문정보
- Research article
- 2022년 09월 (BRIC 등록일 2022-11-15)
- 국내 연구진
- 의약학 > 응용의학
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