한빛사논문
- 조회309
Ju Young Lee 1,17, Sang Hoon Park1,17, Yujin Kim1,2,17, Young Uk Cho 1,17, Jaejin Park1, Jung-Hoon Hong1, Kyubeen Kim1, Jongwoon Shin1, Jeong Eun Ju1, In Sik Min1, Mingyu Sang1, Hyogeun Shin 3, Ui-Jin Jeong3,4, Yuyan Gao5, Bowen Li 5, Aizhan Zhumbayeva 6, Kyung Yeun Kim7,8, Eun-Bin Hong3,9, Min-Ho Nam3,10, Hojeong Jeon7,11, Youngmee Jung6,12, Huanyu Cheng 5,13,14, Il-Joo Cho 2,15 and Ki Jun Yu 1,16
1School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemungu, Seoul 03722, Republic of Korea.
2Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
3Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
4School of Electrical Engineering, Korea University, Seoul 02841, Republic of Korea.
5Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA.
6Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
7Biomaterials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
8Department of Mechanical Engineering, Seoul National University, Seoul 08826, Republic of Korea.
9Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.
10Department of KHU-KIST Convergence Science and Technology, Kyung Hee University, Seoul 02447, Republic of Korea.
11KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea.
12School of Electrical and Electronic Engineering, YU-KIST Institute, Yonsei University, Seoul 03722, Republic of Korea.
13Department of Materials Science and Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
14Materials Research Institute, The Pennsylvania State University, University Park, PA 16802, USA.
15Department of Anatomy, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
16Department of Electrical and Electronic Engineering, YU-Korea Institute of Science and Technology (KIST) Institute, Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
17These authors contributed equally: Ju Young Lee, Sang Hoon Park, Yujin Kim, Young Uk Cho
Corresponding authors: Correspondence to Huanyu Cheng, Il-Joo Cho or Ki Jun Yu.
Abstract
Challenges in the understanding of three-dimensional (3D) brain networks by simultaneously recording both surface and intracortical areas of brain signals remain due to the difficulties of constructing mechanical design and spatial limitations of the implanted sites. Here, we present a foldable and flexible 3D neural prosthetic that facilitates the 3D mapping of complex neural circuits with high spatiotemporal dynamics from the intracortical to cortical region. This device is the tool to map the 3D neural transmission through sophisticatedly designed four flexible penetrating shanks and surface electrode arrays in one integrated system. We demonstrate the potential possibilities of identifying correlations of neural activities from the intracortical area to cortical regions through continuous monitoring of electrophysiological signals. We also exploited the structural properties of the device to record synchronized signals of single spikes evoked by unidirectional total whisker stimulation. This platform offers opportunities to clarify unpredictable 3D neural pathways and provides a next-generation neural interface.
논문정보
- Research article
- 2022년 10월 (BRIC 등록일 2022-11-15)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 의료기기
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