조은경 (충남대학교)

한빛사논문

조회324

충남대학교

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J. Hematol. Oncol., Published: 07 May 2022;15(1):51 | doi: 10.1186/s13045-022-01262-y The dual role of autophagy in acute myeloid leukemia

Wonhyoung Seo ^{1 2 3}, Prashanta Silwal ^{1 2}, Ik-Chan Song ⁴, Eun-Kyeong Jo^{5 6 7}

¹Infection Control Convergence Research Center, Chungnam National University College of Medicine, Daejeon, 35015, Korea.
²Department of Microbiology, Chungnam National University College of Medicine, Daejeon, 35015, Korea.
³Department of Medical Science, Chungnam National University College of Medicine, Daejeon, 35015, Korea.
⁴Division of Hematology/Oncology, Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, 35015, Korea.
⁵Infection Control Convergence Research Center, Chungnam National University College of Medicine, Daejeon, 35015, Korea.
⁶Department of Microbiology, Chungnam National University College of Medicine, Daejeon, 35015, Korea.
⁷Department of Medical Science, Chungnam National University College of Medicine, Daejeon, 35015, Korea.

Corresponding author : Eun-Kyeong Jo

Abstract

Acute myeloid leukemia (AML) is a severe hematologic malignancy prevalent in older patients, and the identification of potential therapeutic targets for AML is problematic. Autophagy is a lysosome-dependent catabolic pathway involved in the tumorigenesis and/or treatment of various cancers. Mounting evidence has suggested that autophagy plays a critical role in the initiation and progression of AML and anticancer responses. In this review, we describe recent updates on the multifaceted functions of autophagy linking to genetic alterations of AML. We also summarize the latest evidence for autophagy-related genes as potential prognostic predictors and drivers of AML tumorigenesis. We then discuss the crosstalk between autophagy and tumor cell metabolism into the impact on both AML progression and anti-leukemic treatment. Moreover, a series of autophagy regulators, i.e., the inhibitors and activators, are described as potential therapeutics for AML. Finally, we describe the translation of autophagy-modulating therapeutics into clinical practice. Autophagy in AML is a double-edged sword, necessitating a deeper understanding of how autophagy influences dual functions in AML tumorigenesis and anti-leukemic responses.

논문정보

형식Review Paper
게재일2022년 05월 (BRIC 등록일 2022-11-08)
연구진국내 연구진
분야 의약학 > 종양의학

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