한빛사논문
- 조회341
서울과학기술대학교
Soomin Jeonga, Soogyeong Janga, Seong Soon Kimb, Myung Ae Baeb, Junnyung Shinc, Ki-Baek Leec, Ki-Tae Kima
aDepartment of Environmental Engineering, Seoul National University of Sciences and Technology, Seoul 01811, the Republic of Korea
bBio & Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon 34114, the Republic of Korea
cZefit Inc., Daegu 42988, the Republic of Korea
Correspondence to: Ki-Tae Kim
Abstract
The effects of polystyrene microplastic (PS-MP) size on neurotoxicity remain to be evaluated at various microsizes, and the seizurogenic effects of PS-MPs are unknown. This study aimed to evaluate the swimming behavior of zebrafish larvae under light–dark transitions after exposure to four PS-MP sizes (i.e., 1, 6, 10, and 25 μm) at concentrations of 500, 5,000, and 50,000 particles/mL. Changes in electroencephalographic signals, seizure-related gene expression, and neurochemical concentrations were measured. Locomotor activity was inhibited only by 10-μm PS-MPs. According to electroencephalographic signals, the number and total duration of seizure-like events significantly increased by 10-μm PS-MPs, which was confirmed by the altered expression of seizure-related genes c-fos and pvalb5. Additionally, an increase in the levels of neurochemicals choline, betaine, dopamine, 3-methoxytyramine, and gamma-aminobutyric acid indicated that the observed hypoactivity and seizure-like behavior were associated with the dysregulation of the cholinergic, dopaminergic, and GABAergic systems. Overall, these findings demonstrate that exposure to PS-MPs can potentially cause seizurogenic effects in developing zebrafish embryos, and we highlight that PS-MPs 10 µm in size dominantly affect neurotoxicity.
논문정보
- Research article
- 2022년 10월 (BRIC 등록일 2022-11-08)
- 국내 연구진
- 생명과학 > 분류/생태/환경생물학
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