한빛사논문
- 조회450
Wonjun Choi1,2,8, Munkyu Kang1,2,8, Jin Hee Hong1,2, Ori Katz3, Byunghak Lee 4,5, Guang Hoon Kim4, Youngwoon Choi 6,7 & Wonshik Choi 1,2
1Center for Molecular Spectroscopy and Dynamics, Institute for Basic Science, Seoul, Republic of Korea.
2Department of Physics, Korea University, Seoul, Republic of Korea.
3Department of Applied Physics, The Selim and Rachel Benin School of Computer Science & Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.
4Korea Electrotechnology Research Institute, Ansan, Korea.
5B2LAB co., ltd, Pohang-si, Gyeongsangbuk, Korea.
6Department of Bioengineering, Korea University, Seoul, Republic of Korea.
7Interdisciplinary Program in Precision Public Health, Korea University, Seoul, Republic of Korea.
8These authors contributed equally: Wonjun Choi, Munkyu Kang.
corresponding authors: Youngwoon Choi, Wonshik Choi
Abstract
Ultrathin lensless fibre endoscopes offer minimally invasive investigation, but they mostly operate as a rigid type due to the need for prior calibration of a fibre probe. Furthermore, most implementations work in fluorescence mode rather than label-free imaging mode, making them unsuitable for general medical diagnosis. Herein, we report a fully flexible ultrathin fibre endoscope taking 3D holographic images of unstained tissues with 0.85-μm spatial resolution. Using a bare fibre bundle as thin as 200-μm diameter, we design a lensless Fourier holographic imaging configuration to selectively detect weak reflections from biological tissues, a critical step for label-free endoscopic reflectance imaging. A unique algorithm is developed for calibration-free holographic image reconstruction, allowing us to image through a narrow and curved passage regardless of fibre bending. We demonstrate endoscopic reflectance imaging of unstained rat intestine tissues that are completely invisible to conventional endoscopes. The proposed endoscope will expedite a more accurate and earlier diagnosis than before with minimal complications.
논문정보
- Research article
- 2022년 08월 (BRIC 등록일 2022-11-07)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 의료기기
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