한빛사논문
- 조회204
Baolei Jia1, Yuanqiang Zou2, Xiao Han3, Jin-Woo Bae4,5,6, Che Ok Jeon1
1Department of Life Science, Chung-Ang University, Seoul 06974, Republic of Korea
2BGI-Shenzhen, Shenzhen 518083, China
3College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China
4Department of Biology, Kyung Hee University, Seoul 02447, Republic of Korea
5Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea
6Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea
Correspondence: Baolei Jia, Che Ok Jeon
Abstract
Cardiovascular disease (CVD) is a health problem worldwide, and elevated cholesterol levels are a key risk factor for the disease. Dysbiotic gut microbiota has been shown to be associated with CVD development. However, the beneficial effects of healthy microbiota in decreasing cholesterol levels have not been summarized. Herein, we begin by discussing the potential mechanisms by which the gut microbiota reduces cholesterol levels. We further sketch the application of probiotics from the genera Lactobacillus and Bifidobacterium in reducing cholesterol levels in clinical studies. Finally, we present the cholesterol-lowering function of beneficial commensal microbes, such as Akkermansia and Bacteroides spp., as these microbes have potential to be the next-generation probiotics (NGPs). The information reviewed in this paper will help people to understand how the gut microbiome might alter cholesterol metabolism and enable the development of NGPs to prevent and treat CVD.
논문정보
- Review Paper
- 2022년 08월 (BRIC 등록일 2022-10-26)
- 국내(교신)+국외 연구진
- 생명과학 > 미생물학
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