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The University of Michigan

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Curr. Biol., Volume 32, Issue 19, 10 October 2022 | https://doi.org/10.1016/j.cub.2022.07.063 High-sucrose diet exposure is associated with selective and reversible alterations in the rat peripheral taste system

Hayeon Sung^1,6, IvaVesela^2,6, Hannah Driks¹, Carrie R. Ferrario^3,4, Charlotte M. Mistretta², Robert M. Bradley^2,5, Monica Dus^1,6

¹Department of Molecular, Cellular, and Developmental Biology, The College of Literature, Arts, and Science, The University of Michigan, Ann Arbor, MI, USA
²Department of Biologic and Materials Sciences & Prosthodontics, School of Dentistry, The University of Michigan, Ann Arbor, MI, USA
³Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, MI, USA
⁴Department of Psychology (Biopsychology), College of Literature, Arts, and Science, The University of Michigan, Ann Arbor, MI, USA
⁵Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, MI, USA

⁶These authors contributed equally
Corresponding authors: Robert M. Bradley, Monica Dus

Abstract

Elevated sugar consumption is associated with an increased risk for metabolic diseases. Whereas evidence from humans, rodents, and insects suggests that dietary sucrose modifies sweet taste sensation, understanding of peripheral nerve or taste bud alterations is sparse. To address this, male rats were given access to 30% liquid sucrose for 4 weeks (sucrose rats). Neurophysiological responses of the chorda tympani (CT) nerve to lingual stimulation with sugars, other taste qualities, touch, and cold were then compared with controls (access to water only). Morphological and immunohistochemical analyses of fungiform papillae and taste buds were also conducted. Sucrose rats had substantially decreased CT responses to 0.15–2.0 M sucrose compared with controls. In contrast, effects were not observed for glucose, fructose, maltose, Na saccharin, NaCl, organic acid, or umami, touch, or cold stimuli. Whereas taste bud number, size, and innervation volume were unaffected, the number of PLCβ2+ taste bud cells in the fungiform papilla was reduced in sucrose rats. Notably, the replacement of sucrose with water resulted in a complete recovery of all phenotypes over 4 weeks. The work reveals the selective and modality-specific effects of sucrose consumption on peripheral taste nerve responses and taste bud cells, with implications for nutrition and metabolic disease risk.

논문정보

형식Research article
게재일2022년 10월 (BRIC 등록일 2022-10-26)
연구진국외 연구진
분야 생명과학 > 신경생물학

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