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Nat. Commun., Published 27 September 2022 | https://doi.org/10.1038/s41467-022-33176-1 Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy

Seong Beom An 1,2,10, Bo-Gie Yang 3,4,10,*, Gyeonghui Jang3, Do-Yeon Kim3, Jiyoung Kim3, Sung-Man Oh3, Nahyun Oh3, Sanghee Lee3, Ji-Yeong Moon5, Jeong-Ah Kim3, Ji-Hyun Kim3, Yoo-Jeong Song3, Hye-Won Hyun3, Jisoo Kim3, Kyungwha Lee3, Dajeong Lee4, Min-Jung Kwak4, Byung Kwon Kim 4, Young-Kyu Park 4, Chun-Pyo Hong3,6, Jung Hwan Kim7, Hye Seong Lim7, Min Sook Ryu5, Hyun-Tak Jin7, Seung-Woo Lee1,2, Yoon-Seok Chang8, Hae-Sim Park 5, Young Chul Sung 1,2,* & Myoung Ho Jang 3,9,*

1Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, Republic of Korea.
2Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, Republic of Korea.
3Research Institute, GI Innovation Inc., Songpa, Seoul, Republic of Korea.
4Research Institute, GI Biome Inc., Seongnam, Gyeonggi-do, Republic of Korea.
5Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Republic of Korea.
6Research Institute, GI Cell Inc., Seongnam, Gyeonggi-do, Republic of Korea.
7Research Institute, ProGen Inc., Korea Bio Park, Seongnam, Gyeonggi-do, Republic of Korea.
8Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
9World Premier International Immunology Frontier Research Center, Osaka University, Suita, Japan.
10These authors contributed equally: Seong Beom An, Bo-Gie Yang.

*Corresponding author.

Abstract

IgE is central to the development of allergic diseases, and its neutralization alleviates allergic symptoms. However, most of these antibodies are based on IgG1, which is associated with an increased risk of fragment crystallizable-mediated side effects. Moreover, omalizumab, an anti-IgE antibody approved for therapeutic use, has limited benefits for patients with high IgE levels. Here, we assess a fusion protein with extracellular domain of high affinity IgE receptor, FcεRIα, linked to a IgD/IgG4 hybrid Fc domain we term IgE_TRAP, to reduce the risk of IgG1 Fc-mediated side effects. IgE_TRAP shows enhanced IgE binding affinity compared to omalizumab. We also see an enhanced therapeutic effect of IgE_TRAP in food allergy models when combined with Bifidobacterium longum, which results in mast cell number and free IgE levels. The combination of IgE_TRAP and B. longum may therefore represent a potent treatment for allergic patients with high IgE levels.

논문정보

형식Research article
게재일2022년 09월 (BRIC 등록일 2022-10-18)
연구진국내(교신)+국외 연구진
분야 생명과학 > 면역학

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