한빛사논문
- 조회485
Xiaoran Yinab1, Yifan Chenga1, Yan Fenga, Wesley R. Stilesb, Seung Hun Parkb, Homan Kangb, Hak Soo Choib
aDepartment of Oncology, The Second Affiliate Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710004, China
bGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
1These authors contributed equally to this work.
Corresponding authors : Homan Kang, Hak Soo Choi
Abstract
Phototheranostics stem from the recent advances in nanomedicines and bioimaging to diagnose and treat human diseases. Since tumors’ diversity, heterogeneity, and instability limit the clinical application of traditional diagnostics and therapeutics, phototheranostics, which combine light-induced therapeutic and diagnostic modalities in a single platform, have been widely investigated. Numerous efforts have been made to develop phototheranostics for efficient light-induced antitumor therapeutics with minimal side effects. Herein, we review the fundamentals of phototheranostic nanomedicines with their biomedical applications. Furthermore, the progress of near-infrared fluorescence imaging and cancer treatments, including photodynamic therapy and photothermal therapy, along with chemotherapy, immunotherapy, and gene therapy, are summarized. This review also discusses the opportunities and challenges associated with the clinical translation of phototheranostics in pan-cancer research. Phototheranostics can pave the way for future research, improve the quality of life, and prolong cancer patients’ survival times.
논문정보
- Review Paper
- 2022년 10월 (BRIC 등록일 2022-10-14)
- 국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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