한빛사논문
- 조회291
Woo-Youl Maeng8,1, Wan-Ling Tseng8,2,3, Song Li4, Jahyun Koo9,1,5 and Yuan-Yu Hsueh9,2,6,7
1 School of Biomedical Engineering, Korea University, Seoul 02841, Republic of Korea
2 Division of Plastic and Reconstructive Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
3 Division of Plastic and Reconstructive Surgery, Department of Surgery, Tainan Hospital, Ministry of Health and Welfare, Tainan 700, Taiwan
4 Department of Bioengineering and Medicine, University of California, Los Angeles, Los Angeles, CA 90095, United States of America
5 Interdisciplinary Program in Precision Public Health, Korea University, Seoul 02841, Republic of Korea
6 International Research Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan 701, Taiwan
7 Center of Cell Therapy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
8 These authors contribute equally to this manuscript.
9 Authors to whom any correspondence should be addressed.
Abstract
Electroceuticals provide promising opportunities for peripheral nerve regeneration, in terms of modulating the extensive endogenous tissue repair mechanisms between neural cell body, axons and target muscles. However, great challenges remain to deliver effective and controllable electroceuticals via bioelectronic implantable device. In this review, the modern fabrication methods of bioelectronic conduit for bridging critical nerve gaps after nerve injury are summarized, with regard to conductive materials and core manufacturing process. In addition, to deliver versatile electrical stimulation, the integration of implantable bioelectronic device is discussed, including wireless energy harvesters, actuators and sensors. Moreover, a comprehensive insight of beneficial mechanisms is presented, including up-to-date in vitro, in vivo and clinical evidence. By integrating conductive biomaterials, 3D engineering manufacturing process and bioelectronic platform to deliver versatile electroceuticals, the modern biofabrication enables comprehensive biomimetic therapies for neural tissue engineering and regeneration in the new era.
논문정보
- Review Paper
- 2022년 09월 (BRIC 등록일 2022-10-14)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오소재
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