한빛사논문
- 조회241
Chuangli Zhang a,1, Jusung An b,1, Jiasheng Wu a,*, Weimin Liu a,c, Hyeonji Rha b, Jong Seung Kim b,*, Pengfei Wang a,c,*
a Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, PR China b Department of Chemistry, Korea University, Seoul, 02841, South Korea c School of Future Technology, University of Chinese Academy of Sciences, Beijing, 100049, PR China
* Corresponding author.
1 These authors contributed equally to this work.
Abstract
Fluorescence bioimaging via the second near-infrared (NIR-II) window can provide precise images with a low background signal due to attenuated absorption and scattering in biological tissues. However, it is challenging to realize organic fluorophores' absorption/emission wavelength beyond 1300 nm depending on their intrinsic emission of monomers. Reducing parasitic aggregation caused quenching (ACQ) effect is expected as an efficient strategy to achieve fluorescence bioimaging in an ideal region. Herein, two NIR-II xanthene fluorophores (CM1 and CM2) with different side chains on identical skeletons were synthesized. Besides, their corresponding assemblies (CM1 NPs and CM2 NPs) were subsequently prepared, which exhibited distinct spectroscopic properties. Notably, CM2 NPs exhibited a significantly reduced ACQ effect with maximal absorption/emission extended to 1235/1250 nm. Molecular dynamics simulations revealed that intermolecular hydrogen bond, π-π interaction, and CH-π interaction of CM2 were essential for the reduced ACQ effect. In vivo hindlimb angiography showed that CM2 NPs could distinguish the neighboring artery and vein in high resolution. Besides, CM2 NPs could achieve angiography beyond 1300 nm and even resolve capillaries as small as 0.23 mm. This study provides a new strategy for reducing the ACQ effect by controlling different side chains of NIR-II xanthene dyes for angiography beyond 1300 nm.
논문정보
- Research article
- 2022년 09월 (BRIC 등록일 2022-10-12)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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