한빛사논문
Tae-Hyun Kima1, JunYoung Leeb1, Jing Xiec, JeongHoon Parkb, Jae-Min Ohc
aDepartment of Environmental Engineering, Seoul National University of Science and Technology, Seoul 01811, South Korea
bAccelerator & Radioisotopes Development Laboratory, Korea Atomic Energy Research Institute, Jeongeup 56212, South Korea
cDepartment of Energy and Materials Engineering, Dongguk University-Seoul, Seoul 04620, South Korea
1Both authors equally contributed to the manuscript.
Corresponding authors: Jeong Hoon Park; Jae-Min Oh
Abstract
Layered double hydroxide is a family of two-dimensional materials with wide range of compositions. Recently, its ability to accommodate various chemical species and biocompatibility have been attracted in the biomedical applications to develop drug delivery system and nanodiagnostics. In this review, we categorized biomedical approaches of layered double hydroxide with respect to the three topologies of, namely, interlayer space, outer surface with particle edge, and the lattice points. There have been extensive researches on the intercalation of drug or tracing to make use of interlayer space of layered double hydroxide for drug stabilization, sustained release, cellular delivery and etc. Outer surface or edge has been utilized to immobilization of large therapeutic moieties and to attach tracing moiety. Lattice points consisting of various metal species could be utilized for the specific metal species like paramagnetic elements or radioisotopes. Based on these topologies in layered double hydroxide, both the synthetic routes and the achieved functionalities in terms of biomedical application will be discussed.
논문정보
관련 링크
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기