한빛사논문
- 조회342
Hyoryung Nam 1, Yoo-Mi Choi 2, Sungkeon Cho 3, Ge Gao 4, Donghwan Kim 5, Jongmin Kim 3, Hwanyong Choi 6, Se-Hwan Lee 7, Jinah Jang 8
1Department of Convergence IT Engineering, Pohang University of Science and Technology, POSTECH, Pohang, Gyeongsangbuk-do, 37673, Korea (the Republic of).
2Department of Convergence IT Engineering, Pohang University of Science and Technology (POSTECH), 80, Jigok-ro, Nam-gu, Pohang, Gyeongsangbuk-do, 37666, Korea (the Republic of).
3Department of Mechanical Engineering, Pohang University of Science and Technology, POSTECH, Pohang, Gyeongsangbuk-do, 37673, Korea (the Republic of).
4Pohang University of Science and Technology, POSTECH, Pohang, Gyeongsangbuk-do, 37673, Korea (the Republic of).
5School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, POSTECH, Pohang, Gyeongsangbuk-do, 37673, Korea (the Republic of).
6Pohang University of Science and Technology, Department of Mechanical Engineering, Pohang, Gyeongsangbuk-do, 37673, Korea (the Republic of).
7Department of Convergence IT Engineering, Pohang University of Science and Technology (POSTECH), Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang 37673, Republic of Korea, Pohang, 37673, Korea (the Republic of).
8Department of Convergence IT Engineering, Pohang University of Science and Technology (POSTECH), POSTECH, Pohang, 37673, Korea (the Republic of).
Abstract
In vitro organ models allow for the creation of precise preclinical models that mimic organ physiology. During a pandemic of a life-threatening acute respiratory disease, an improved trachea model is required. We fabricated a modular assembly of the blood vessel and trachea models using 3D bioprinting technology. First, decellularized extracellular matrix (dECM) were prepared using the porcine trachea and blood vessels. A trachea module was fabricated based on the tracheal mucosa-derived dECM and microporous membrane. Further, a blood vessel module was manufactured using the prepared vascular-tissue-derived dECM. By assembling each manufactured module, a perfusable vascularized trachea model simulating the interface between the tracheal epithelium and blood vessels was fabricated. This assembled model was manufactured with efficient performance, and it offered respiratory symptoms, such as inflammatory response and allergen-induced asthma exacerbation. These characteristics indicate the possibility of manufacturing a highly functional organ model that mimics a complex organ environment in the future.
논문정보
- Research article
- 2022년 09월 (BRIC 등록일 2022-10-14)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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