김기수 (부산대학교) | 한빛사논문 > 한빛사

한빛사논문

조회232

부산대학교

CV File 109 kb

Adv. Drug Deliv. Rev., Available online 7 July 2022 Sep;188:114419 | https://doi.org/10.1016/j.addr.2022.114419 Upconversion nanomaterials and delivery systems for smart photonic medicines and healthcare devices

Gibum Lee^a, Hye Eun Choi^b, Sang Hoon Hong^a, Minji Choi^a, Dong-Wook Han^c, Junmin Lee^a, Ki Su Kim^b, Sei Kwang Hahn^a

^aDepartment of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, Republic of Korea
^bSchool of Chemical Engineering, College of Engineering, Pusan National University, 2 Busandaehak-ro 63 been-gil, Geumjeong-gu, Busan 46241, Republic of Korea
^cDepartment of Optics and Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, 2 Busandaehak-ro 63 beon-gil, Geumjeong-gu, Busan, 46241, Republic of Korea

Corresponding authors: Ki Su Kim; Sei Kwang Hahn

Abstract

In the past decade, upconversion (UC) nanomaterials have been extensively investigated for the applications to photomedicines with their unique features including biocompatibility, near-infrared (NIR) to visible conversion, photostability, controllable emission bands, and facile multi-functionality. These characteristics of UC nanomaterials enable versatile light delivery for deep tissue biophotonic applications. Among various stimuli-responsive delivery systems, the light-responsive delivery process has been greatly advantageous to develop spatiotemporally controllable on-demand “smart” photonic medicines. UC nanomaterials are classified largely to two groups depending on the photon UC pathway and compositions: inorganic lanthanide-doped UC nanoparticles and organic triplet–triplet annihilation UC (TTA-UC) nanomaterials. Here, we review the current-state-of-art inorganic and organic UC nanomaterials for photo-medicinal applications including photothermal therapy (PTT), photodynamic therapy (PDT), photo-triggered chemo and gene therapy, multimodal immunotherapy, NIR mediated neuromodulations, and photochemical tissue bonding (PTB). We also discuss the future research direction of this field and the challenges for further clinical development.

논문정보

형식Review Paper
게재일2022년 07월 (BRIC 등록일 2022-10-11)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

댓글 작성 로그인

CV 열람하기

연락처 보기