박진우 (연세대학교, 에이슨) | 한빛사논문 > 한빛사

한빛사논문

조회337

연세대학교, 에이슨

Biosens. Bioelectron., Available online 16 July 2022 | https://doi.org/10.1016/j.bios.2022.114555 A fabric-based multifunctional sensor for the early detection of skin decubitus ulcers

Seung-Rok Kim^a,1, Soyeon Lee^a,b,1, Jihee Kim^c,d,e,1, Eunbin Kim^c,d, Hye-Jun Kil^a, Ju-Hyun Yoo^a, Je-Heon Oh^a, Jiwan Jeon^a, Ey-In Lee^a, Jun-Woo Jeon^a, Kun-Hoo Jeon^a, Ju Hee Lee^c,d, Jin-Woo Park^a,b

^aDepartment of Materials Science and Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea
^bAsen Company, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea
^cDepartment of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, College of Medicine, Yonsei University, Seoul, 03722, South Korea
^dScar Laser and Plastic Surgery Center, Yonsei Cancer Hospital, College of Medicine, Yonsei University, Seoul, 03722, South Korea
^eDepartment of Dermatology, Yongin Severance Hospital, Yongin, 16995, South Korea

¹These authors contributed equally.
Corresponding authors: Ju Hee Lee; Jin-Woo Park

Abstract

Monitoring biosignals at the skin interface is necessary to suppress the potential for decubitus ulcers in immobile patients confined to bed. We develop conformally contacted, disposable, and breathable fabric-based electronic devices to detect skin impedance, applied pressure, and temperature, simultaneously. Based on the experimental evaluation of the multifunctional sensors, a combination of robust AgNW electrodes, soft ionogel capacitive pressure sensor, and resistive temperature sensor on fabric provides alarmed the initiation of early-stage decubitus ulcers without signal distortion under the external stimulus. For clinical verification, an animal model is established with a pair of magnets to mimic a human decubitus ulcers model in murine in vivo. The evidence of pressure-induced ischemic injury is confirmed with the naked eye and histological and molecular biomarker analyses. Our multifunctional integrated sensor detects the critical time for early-stage decubitus ulcer, establishing a robust correlation with the biophysical parameters of skin ischemia and integrity, including temperature and impedance.

논문정보

형식Research article
게재일2022년 07월 (BRIC 등록일 2022-10-26)
연구진국내 연구진
분야 의약학 > 응용의학

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