한빛사논문
Jeongbin Park, Jinyeong Choi, Jae Eun Lee, Hongyoon Choi,* and Hyung-Jun Im*
J. Park, H.-J. Im
Department of Molecular Medicine and Biopharmaceutical Sciences
Graduate School of Convergence Science and Technology
Seoul National University
Seoul 08826, Republic of Korea
J. Choi, H.-J. Im
Department of Applied Bioengineering
Graduate School of Convergence Science and Technology
Seoul National University
Seoul 08826, Republic of Korea
J. E. Lee
Portrai Inc
Seoul 03136, Republic of Korea
H. Choi
Department of Nuclear Medicine
Seoul National University College of Medicine
Seoul 03080, Republic of Korea
H. Choi
Department of Nuclear Medicine
Seoul National University Hospital
Seoul 03080, Republic of Korea
H.-J. Im
Cancer Research Institute
Seoul National University
Seoul 03080, Republic of Korea
H.-J. Im
Research Institute for Convergence Science
Seoul National University
Seoul 08826, Republic of Korea
J.P. and J.C. contributed equally to this work.
*Corresponding author.
Abstract
The intratumoral accumulation of nanomedicine has been considered a passive process, referred to as the enhanced permeability and retention effect. Recent studies have suggested that the tumor uptake of nanomedicines follows an energy-dependent pathway rather than being a passive process. Herein, to explore the factor candidates that are associated with nanomedicine tumor uptake, a molecular marker identification platform is developed by integrating microscopic fluorescence images of a nanomedicine distribution with spatial transcriptomics information. When this approach is applied to PEGylated liposomes, molecular markers related to hypoxia, glycolysis, and apoptosis can be identified as being related to the intratumoral distribution of the nanomedicine. It is expected that the method can be applied to explain the distribution of a wide range of nanomedicines and that the data obtained from this analysis can enhance the precise utilization of nanomedicines.
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