한빛사논문
- 조회448
Sungwoo Leea,¶, Hyun Soo Shimb,c,¶, Hyeok Ju Park b,f, Yujung Changc, Young-eun Hand, Soo-Jin Ohd,e, Wonwoong Lee g, Hyeonjoo Imb,h, YunHee Seol d, Hoon Ryud, Hoon Kang b,c, Yong Kyu Leef, Sungho Parka,∗, Junsang Yoo b,c,∗
a Department of Chemistry, Sungkyunkwan University, 2066, Seobu-ro, Jangan-gu, Suwon-si, Gyeongki-do, 16419, Republic of Korea b Laboratory of regenerative medicine for neurodegenerative disease, Stand Up Therapeutics, Hannamdaero 98, Seoul, 04418, Republic of Korea c Department of Molecular biology, Nuturn Science, Sinsadong 559-8, Seoul, 06037, Republic of Korea d Brain Science Institute, Korea Institute of Science and Technology (KIST), Hwarang-ro 14-gil, Seongbuk-gu, Seoul, 02792, Republic of Korea e Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Hwarang-ro 14-gil, Seongbuk-gu, Seoul, 02792, Republic of Korea f Database Laboratory, Department of Computer Science and Engineering, Dongguk University-Seoul, Pildong-ro 1-gil 30, Jung-gu, Seoul, 04620, Republic of Korea g College of Pharmacy, Woosuk University, 443, Samnye-ro, Samnye-eup, Wanju_Gun, Jeollabuk-do, 55338, Republic of Korea h Department of Anatomy, College of Medicine, Korea University, 145, Anam-ro, Seongbuk-gu, Seoul, 20841, Republic of Korea Seoul
∗ Corresponding author.
¶ These authors contributed equally.
Abstract
The efficient production of dopaminergic neurons via the direct conversion of other cell types is of interest as a potential therapeutic approach for Parkinson's disease. This study aimed to investigate the use of elongated porous gold nanorods (AuNpRs) as an enhancer of cell fate conversion. We observed that AuNpRs promoted the direct conversion of fibroblasts into dopaminergic neurons in vivo and in vitro. The extent of conversion of fibroblasts into dopaminergic neurons depended on the porosity of AuNpRs, as determined by their aspect ratio. The mechanism underlying these results involves specific AuNpR-induced transcriptional changes that altered the expression of antioxidant-related molecules. The generation of dopaminergic neurons via the direct conversion method will open a new avenue for developing a therapeutic platform for Parkinson's disease treatment.
논문정보
- Research article
- 2022년 10월 (BRIC 등록일 2022-10-06)
- 국내 연구진
- 의약학 > 재생의학
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