한빛사논문
- 조회235
Giwoong Choi1, Hojun Yoon1, Hyun Ho Choi1, Kyoung Hwa Ha2, Dae Jung Kim2
1Ajou University School of Medicine, Suwon, Republic of Korea
2Depar tment of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea
Address correspondence to: Kyoung Hwa Ha, Dae Jung Kim
Abstract
Background
active screening can improve health outcomes for people with prediabetes. However, its efficacy in older adults remains uncertain.
Objective
the study aimed to analyse the progression from prediabetes to diabetes in older adults, including associated complications and mortality rates, to determine the benefits of active screening.
Design
retrospective cohort study.
Setting
Korean National Health Insurance Service claims database.
Subjects
a total of 36,946 adults aged ≥65 years who underwent national health examinations from 2006 to 2008.
Methods
follow-up was until 31 December 2015. Cox’s proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for death and diabetic complications.
Results
over a median follow-up of 8.2 years, 19.3% of older adults with prediabetes progressed to diabetes. Compared with normoglycaemic adults, the multivariable-adjusted HRs (95% CI) for major adverse cardiovascular events were 1.01 (0.95–1.07), 1.08 (0.95–1.23), 1.14 (1.05–1.23) and 1.50 (1.35–1.68) in adults with prediabetes, newly diagnosed diabetes, diabetes not on insulin and diabetes on insulin, respectively. The corresponding HRs (95% CI) for diabetic retinopathy risk were 1.28 (1.15–1.43), 3.16 (2.71–3.69), 6.58 (6.02–7.19) and 9.17 (8.21–10.24). Diabetic nephropathy risk also significantly increased.
Conclusions
progression from prediabetes to diabetes is an important concern among older adults. Prediabetes is associated with the risk of microvascular complications, but not cardiovascular complications and mortality. Therefore, active regular screening for prediabetes is necessary to prevent microvascular complications.
논문정보
- Research article
- 2022년 06월 (BRIC 등록일 2022-10-25)
- 국내 연구진
- 의약학 > 응용의학
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