한빛사논문
- 조회166
Jong Keon Jang*, Eun Sun Lee*, Jung Wook Seo, Youe Ree Kim, So Yeon Kim, Young Youn Cho, Dong Ho Lee
From the Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea (J.K.J., S.Y.K.); Departments of Radiology (E.S.L.) and Internal Medicine (Y.Y.C.), Chung-Ang University Hospital, Seoul, Korea; Department of Radiology, Ilsan Paik Hospital, Inje University College of Medicine, Gyeonggi, Korea (J.W.S.); Department of Radiology, Wonkwang University Hospital, Wonkwang University College of Medicine, Iksan, Korea (Y.R.K.); and Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea (D.H.L.).
Address correspondence to D.H.L.
* J.K.J. and E.S.L. contributed equally to this work.
Abstract
A risk score system based on attenuation coefficient and two-dimensional shear-wave elastography showed the best diagnostic performance for nonalcoholic steatohepatitis compared with serum markers or other US parameters alone.
Background
Multiparametric US examination may have potential in the comprehensive evaluation of nonalcoholic fatty liver disease (NAFLD), but multicenter studies are lacking.
Purpose
To evaluate the diagnostic performance of multiparametric US with the attenuation coefficient (AC) from attenuation imaging (ATI) and liver stiffness (LS) and dispersion slope (DS) from two-dimensional (2D) shear-wave elastography (SWE) in a multicenter study of patients with NAFLD.
Materials and Methods
This prospective study enrolled consecutive participants between December 2019 and June 2021 with suspected nonalcoholic steatohepatitis (NASH) who were scheduled to undergo liver biopsy in five tertiary hospitals. Before the procedure, all participants underwent US with ATI and 2D SWE according to the study protocol. Multivariable linear regression analyses were performed to determine the significant determinant factors for AC, LS, and DS. Diagnostic performance was decided based on the areas under the receiver operating characteristic curve (AUCs).
Results
A total of 132 participants (median age, 38 years; IQR, 27–54 years; 69 women) were evaluated. Among the participant characteristics, including pathologic findings, demographic characteristics, body mass index, and serum markers, hepatic steatosis for AC (P < .001), lobular inflammatory activity for DS (P = .007), and both fibrosis (P = .01) and lobular inflammatory activity (P = .04) for LS were significant determinant factors. At histopathologic examination, 53 of the 132 participants (40.2%) had NASH. The risk score system obtained using unweighted sum of scores from AC and DS showed the best diagnostic performance in the detection of NASH (AUC = 0.94; 95% CI: 0.89, 0.98; P < .05 for all), as compared with serum markers or other US parameters alone (AUC ≤ 0.88).
Conclusion
US attenuation imaging and two-dimensional shear-wave elastography were useful for assessing hepatic steatosis, lobular inflammation, and fibrosis. The risk score system obtained using the attenuation coefficient and dispersion slope showed the best diagnostic performance fo r nonalcoholic steatohepatitis.
논문정보
- Research article
- 2022년 06월 (BRIC 등록일 2022-10-27)
- 국내 연구진
- 의약학 > 응용의학
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