한성 (Salk Institute for Biological Studies)

한빛사논문

조회441

Salk Institute for Biological Studies

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Cell Reports, Volume 40, Issue 7, 16 August 2022, 111222 | https://doi.org/10.1016/j.celrep.2022.111222 A central alarm system that gates multi-sensory innate threat cues to the amygdala

Sukjae J. Kang,1,9 Shijia Liu,1,2,9 Mao Ye,1 Dong-Il Kim,1 Gerald M. Pao,3,4 Bryan A. Copits,5,6 Benjamin Z. Roberts,7 Kuo-Fen Lee,1 Michael R. Bruchas,8 and Sung Han1,2,7,10,*

1Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
2Department of Neurobiology, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
3Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
4Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Okinawa 904-0495, Japan
5Washington University Pain Center, Washington University School of Medicine, St. Louis, MO 63110, USA
6Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA
7Neurosciences Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA
8Center of Excellence in the Neurobiology of Addiction, Pain, and Emotion, Departments of Anesthesiology and Pain Medicine, and Pharmacology, University of Washington, Seattle, WA 98195, USA
9These authors contributed equally
10Lead contact
*Correspondence

Abstract

Perception of threats is essential for survival. Previous findings suggest that parallel pathways independently relay innate threat signals from different sensory modalities to multiple brain areas, such as the midbrain and hypothalamus, for immediate avoidance. Yet little is known about whether and how multi-sensory innate threat cues are integrated and conveyed from each sensory modality to the amygdala, a critical brain area for threat perception and learning. Here, we report that neurons expressing calcitonin gene-related peptide (CGRP) in the parvocellular subparafascicular nucleus in the thalamus and external lateral parabrachial nucleus in the brainstem respond to multi-sensory threat cues from various sensory modalities and relay negative valence to the lateral and central amygdala, respectively. Both CGRP populations and their amygdala projections are required for multi-sensory threat perception and aversive memory formation. The identification of unified innate threat pathways may provide insights into developing therapeutic candidates for innate fear-related disorders.

논문정보

형식Research article
게재일2022년 08월 (BRIC 등록일 2022-09-28)
연구진국외 연구진
분야 생명과학 > 신경생물학

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