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Adv. Drug Deliv. Rev., Volume 187, August 2022, 114399 | https://doi.org/10.1016/j.addr.2022.114399 Implantable Micro-Light-Emitting Diode (µLED)-based optogenetic interfaces toward human applications

JaeHee Leea, Sinjeong Leeb, Daesoo Kimb, KeonJae Leea*

aDepartment of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea
bDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea

*Corresponding author.

Abstract

Optogenetics has received wide attention in biomedical fields because of its advantages in temporal precision and spatial resolution. Beyond contributions to important advances in fundamental research, optogenetics is inspiring a shift towards new methods of improving human well-being and treating diseases. Soft, flexible and biocompatible systems using µLEDs as a light source have been introduced to realize brain-compatible optogenetic implants, but there are still many technical challenges to overcome before their human applications. In this review, we address progress in the development of implantable µLED probes and recent achievements in (i) device engineering design, (ii) driving power, (iii) multifunctionality and (iv) closed-loop systems. (v) Expanded optogenetic applications based on remarkable advances in µLED implants will also be discussed.

논문정보

형식Review Paper
게재일2022년 08월 (BRIC 등록일 2022-10-05)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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