유수웅 (전남대학교 의과대학)

한빛사논문

조회422

전남대학교 의과대학

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Adv. Drug Deliv. Rev., Volume 187, August 2022, 114366 | https://doi.org/10.1016/j.addr.2022.114366 Molecular imaging approaches to facilitate bacteria-mediated cancer therapy

Su Woong Yoo ^a,1, Seong Young Kwon ^a,b,1, Sae-Ryung Kang ^a, Jung-Joon Min ^a,b,⇑

^aDepartment of Nuclear Medicine, Chonnam National University Hwasun Hospital, Hwasun, Jeonnam, Korea
^bDepartment of Nuclear Medicine, Chonnam National University Medical School, Hwasun, Jeonnam, Korea

^⇑Corresponding author.
¹These authors contributed equally to this work.

Abstract

Bacteria-mediated cancer therapy is a potential therapeutic strategy for cancer that has unique properties, including broad tumor-targeting ability, various administration routes, the flexibility of delivery, and facilitating the host’s immune responses. The molecular imaging of bacteria-mediated cancer therapy allows the therapeutically injected bacteria to be visualized and confirms the accurate delivery of the therapeutic bacteria to the target lesion. Several hurdles make bacteria-specific imaging challenging, including the need to discriminate therapeutic bacterial infection from inflammation or other pathologic lesions. To realize the full potential of bacteria-specific imaging, it is necessary to develop bacteria-specific targets that can be associated with an imaging assay. This review describes the current status of bacterial imaging techniques together with the advantages and disadvantages of several imaging modalities. Also, we describe potential targets for bacterial-specific imaging and related applications.

논문정보

형식Review Paper
게재일2022년 08월 (BRIC 등록일 2022-09-20)
연구진국내 연구진
분야 의약학 > 응용의학

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