한빛사논문
- 조회374
Kyung Ho Kim+, Sung Eun Seo+, Chul Soon Park, Soomin Kim, Soohyun Lee, Choong-Min Ryu, Dongeun Yong, Yoo Min Park, and Oh Seok Kwon*
[*] K. H. Kim,+ S. E. Seo,+ Dr. C. S. Park, S. Kim, S. Lee, Dr. C.-M. Ryu, Dr. O. S. Kwon
Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB) Daejeon 34141 (Republic of Korea)
Prof. D. Yong
Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine Seoul (Republic of Korea)
Dr. Y. M. Park
Division of Nano-Bio Sensors/Chips Development, National NanoFab Center (NNFC) Daejeon (Republic of Korea)
Dr. O. S. Kwon
College of Biotechnology and Bioengineering, Sungkyunkwan University Suwon 16419 (Republic of Korea)
[+] These authors contributed equally
*Corresponding author.
Abstract
Organic interfacial compounds (OICs) are required as linkers for the highly stable and efficient immobilization of bioprobes in nanobiosensors using 2D nanomaterials such as graphene. Herein, we first demonstrated the fabrication of a field-effect transistor (FET) via a microelectromechanical system process after covalent functionalization on large-scale graphene by introducing oligo(phenylene-ethynylene)amine (OPE). OPE was compared to various OICs by density functional theory simulations and was confirmed to have a higher binding energy with graphene and a lower band gap than other OICs. OPE can improve the immobilization efficiency of a bioprobe by forming a self-assembly monolayer via anion-based reaction. Using this technology, Magainin I-conjugated OGMFET (MOGMFET) showed a high sensitivity, high selectivity, with a limit of detection of 100 cfu mL−1. These results indicate that the OPE OIC can be applied for stable and comfortable interfacing technology for biosensor fabrication.
논문정보
- Research article
- 2022년 08월 (BRIC 등록일 2022-09-16)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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