이승호 (Massachusetts Institute of Technology) | 한빛사논문 > 한빛사

한빛사논문

조회434

Massachusetts Institute of Technology

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Biomaterials, Volume 288, September 2022, 121703 | https://doi.org/10.1016/j.biomaterials.2022.121703 Biodegradable ring-shaped implantable device for intravesical therapy of bladder disorders

Hyunjoon Kim ^a,1, Seung Ho Lee ^a,1, Adam Wentworth ^a,b, Sahab Babaee ^a, Kaitlyn Wong ^b, Joy E. Collins ^b, Jacqueline Chu ^a,c, Keiko Ishida ^a,b, Johannes Kuosmanen ^a, Joshua Jenkins ^a, Kaitlyn Hess ^a, Aaron Lopes ^a,b, Joshua Morimoto ^a, Qianqian Wan ^a, Shaunak V. Potdar ^b, Ronan McNally ^b, Caitlynn Tov ^b, Na Yoon Kim ^a, Alison Hayward ^a,b,d, Daniel Wollin ^e, Robert Langer ^a,f,g, Giovanni Traverso ^a,b,g,*

^a The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA ^b Division of Gastroenterology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA ^c Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA ^d Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA ^e Division of Urology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA ^f Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA ^g Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA

^* Corresponding author.
¹ These authors contributed equally: Hyunjoon Kim, SeungHo Lee.

Abstract

Intravesical instillation is an efficient drug delivery route for the local treatment of various urological conditions. Nevertheless, intravesical instillation is associated with several challenges, including pain, urological infection, and frequent clinic visits for catheterization; these difficulties support the need for a simple and easy intravesical drug delivery platform. Here, we propose a novel biodegradable intravesical device capable of long-term, local drug delivery without a retrieval procedure. The intravesical device is composed of drug encapsulating biodegradable polycaprolactone (PCL) microcapsules and connected by a bioabsorbable Polydioxanone (PDS) suture with NdFeB magnets in the end. The device is easily inserted into the bladder and forms a ‘ring’ shape optimized for maximal mechanical stability as informed by finite element analysis. In this study, inserted devices were retained in a swine model for 4 weeks. Using this device, we evaluated the system's capacity for delivery of lidocaine and resiquimod and demonstrated prolonged drug release. Moreover, a cost-effectiveness analysis supports device implementation compared to the standard of care. Our data support that this device can be a versatile drug delivery platform for urologic medications.

논문정보

형식Research article
게재일2022년 09월 (BRIC 등록일 2022-09-14)
연구진국외 연구진
분야 의약학 > 약학

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