한빛사논문
- 조회541
Jun-Hyeok Han a,b,1, Yun Young Lee c,d,1, Ha Eun Shin a, Jieun Han a, Jeon Min Kang e, Chi-Pin James Wang d,f, Jung-Hoon Park e, Se-Na Kim g, Jong-Hwi Yoon h, Ho-Keun Kwon h, Dae-Hwan Park i, Tae-Eun Park j, Young Bin Choy c,g, Dong-Hyun Kim k,l,m,n, Tae-Hyung Kim o, Junhong Min o, Ik-Hwan Kim p, Chun Gwon Park d,f,q,r,*, Dong Keun Han s,*, Wooram Park a,*
a Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Seoburo 2066, Suwon, Gyeonggi, 16419, Republic of Korea
b Department of Biotechnology, Korea University, Seoul, 02841, Republic of Korea
c Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea
d Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea
e Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, 05505, Republic of Korea
f Department of Intelligent Precision Healthcare Convergence, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea
g Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University, Seoul, 03080, Republic of Korea
h Department of Microbiology and Immunology, Institute for Immunology and Immunological Diseases and Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea
i Department of Engineering Chemistry, Chungbuk National University, Cheongju, Chungbuk, 28644, Republic of Korea
j Department of Biomedical Engineering, College of Information-Bio Convergence Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea
k Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, 60611, USA
l Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois, 60611, USA
m Department of Biomedical Engineering, McCormick School of Engineering, Evanston, Illinois, 60208, USA
n Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, 60607, USA
o School of Integrative Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Republic of Korea
p Division of Life Sciences, Korea University, Seoul, 02841, Republic of Korea
q Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Gyeonggi, 16419, Republic of Korea
r Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon, Gyeonggi, 16419, Republic of Korea
s Department of Biomedical Science, CHA University, Seongnam, Gyeonggi, 13496, Republic of Korea
* Corresponding author.
1 These authors contributed equally to this work.
Abstract
Cancer immunotherapy is a next-generation treatment strategy; however, its side effects limit its clinical translation. Here, a novel combination of a multi-functional nano-adjuvant (M-NA) prepared with an iron oxide/gold core and a cationic polymer shell via multilayer synthesis with CpG oligodeoxynucleotide (CpG-ODN) electrostatically complexed on its surface, and irreversible electroporation (IRE) technique was developed for effective image-guided in situ cancer vaccination. The M-NA can be retained long-term in the dense tumoral extracellular matrix after intratumoral injection and internalized by antigen-presenting cells (APCs). The IRE can induce immunogenic cell death. Indeed, in a mouse tumor model, the M-NA showed longer tumor retention time than free CpG-ODN. Compared with other treatments, the combined treatment significantly inhibited tumor growth with 100% survival rate for ∼60 days. The therapy induced the activation of cytotoxic lymphocytes and the maturation of APCs in vivo. This treatment could be effective in image-guided local cancer immunotherapy.
논문정보
- Research article
- 2022년 08월 (BRIC 등록일 2022-09-08)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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