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Trends Genet., Available online 3 July 2022 | https://doi.org/10.1016/j.tig.2022.06.009 Resolving m6A epitranscriptome with stoichiometry

Ki-Jun Yoon^1,2,*, Yoon Ki Kim^1,3,4,*

¹Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea
²KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea
³Creative Research Initiatives Center for Molecular Biology of Translation, Korea University, Seoul, Republic of Korea
⁴Division of Life Sciences, Korea University, Seoul 02841, Republic of Korea

^*Corresponding author.

Abstract

A recent study by Hu et al. describes N⁶-methyladenosine (m⁶A)-selective allyl chemical labeling and sequencing (m⁶A-SAC-seq), which allows for quantitative, stoichiometric, and positional analyses of m⁶A at single-nucleotide resolution across the whole transcriptome level. Information on the m⁶A stoichiometry will provide additional layers of gene regulatory pathways mediated by m⁶A modification during diverse molecular, cellular, and physiological events.

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형식Spotlight
게재일2022년 07월 (BRIC 등록일 2022-09-05)
연구진국내 연구진
분야 생명과학 > 분자생물학

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