한빛사논문
- 조회702
Soohwan An, Eun Je Jeon, Seung Yeop Han, Jihoon Jeon, Mi Jeong Lee, Sooyeon Kim, Mikyung Shin, and Seung-Woo Cho*
S. An, E. J. Jeon, S. Y. Han, J. Jeon, M. J. Lee, S. Kim, S.-W. Cho
Department of Biotechnology
Yonsei University
Seoul 03722, Republic of Korea
E. J. Jeon, S.-W. Cho
CellArtgen Inc.
Seoul 03722, Republic of Korea
M. Shin
Department of Biomedical Engineering
Sungkyunkwan University (SKKU)
Suwon 16419, Republic of Korea
M. Shin
Department of Intelligent Precision Healthcare Convergence
Sungkyunkwan University (SKKU)
Suwon 16419, Republic of Korea
S.-W. Cho
Center for Nanomedicine
Institute for Basic Science (IBS)
Seoul 03722, Republic of Korea
S.-W. Cho
Graduate Program of Nano Biomedical Engineering (NanoBME)
Advanced Science Institute
Yonsei University
Seoul 03722, Republic of Korea
*Corresponding author.
Abstract
Catechol, a major mussel-inspired underwater adhesive moiety, has been used to develop functional adhesive hydrogels for biomedical applications. However, oxidative catechol chemistry for interpolymer crosslinking and adhesion is exclusively effective under alkaline conditions, with limited applications in non-alkaline conditions. To overcome this limitation, pH-universal catechol–amine chemistry to recapitulate naturally occurring biochemical events induced by pH variation in the mussel foot is suggested. Aldehyde moieties are introduced to hyaluronic acid (HA) by partial oxidation, which enables dual-mode catechol tethering to the HA via both stable amide and reactive secondary amine bonds. Because of the presence of additional reactive amine groups, the resultant aldehyde-modified HA conjugated with catechol (AH-CA) is effectively crosslinked in acidic and neutral pH conditions. The AH-CA hydrogel exhibits not only fast gelation via active crosslinking regardless of pH conditions, but also strong adhesion and excellent biocompatibility. The hydrogel enables rapid and robust wound sealing and hemostasis in neutral and alkaline conditions. The hydrogel also mediates effective therapeutic stem cell and drug delivery even in dynamic and harsh environments, such as a motile heart and acidic stomach. Therefore, the AH-CA hydrogel can serve as a versatile biomaterial in a wide range of pH conditions in vivo.
논문정보
- Research article
- 2022년 08월 (BRIC 등록일 2022-08-29)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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