한빛사논문
- 조회633
Junil Kim1, Hyerim Lee1, Sun-Ju Yi2,* and Kyunghwan Kim1,*
1Department of Biological Sciences and Biotechnology, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea. 2Center for Ecology and Environmental Toxicology, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea.
*Corresponding author.
Abstract
Oxygen, which is necessary for sustaining energy metabolism, is consumed in many biochemical reactions in eukaryotes. When the oxygen supply is insufficient for maintaining multiple homeostatic states at the cellular level, cells are subjected to hypoxic stress. Hypoxia induces adaptive cellular responses mainly through hypoxia-inducible factors (HIFs), which are stabilized and modulate the transcription of various hypoxia-related genes. In addition, many epigenetic regulators, such as DNA methylation, histone modification, histone variants, and adenosine triphosphate-dependent chromatin remodeling factors, play key roles in gene expression. In particular, hypoxic stress influences the activity and gene expression of histone-modifying enzymes, which controls the posttranslational modification of HIFs and histones. This review covers how histone methylation and histone acetylation enzymes modify histone and nonhistone proteins under hypoxic conditions and surveys the impact of epigenetic modifications on gene expression. In addition, future directions in this area are discussed.
논문정보
- Review Paper
- 2022년 07월 (BRIC 등록일 2022-08-29)
- 국내 연구진
- 생명과학 > 유전자발현
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