송원석 (University of California Irvine) | 한빛사논문 > 한빛사

한빛사논문

조회396

University of California Irvine

Annu. Rev. Nutr., Vol. 42:45-66 (Volume publication date August 2022) | https://doi.org/10.1146/annurev-nutr-062220-025831 Dietary Fructose and Fructose-Induced Pathologies

Sunhee Jung,^1,∗ Hosung Bae,^1,∗ Won-Suk Song,^1,2,∗ and Cholsoon Jang^1,3,4,5

¹Department of Biological Chemistry, University of California, Irvine, California, USA;
²Institute of Bioengineering, Bio-MAX, Seoul National University, Seoul, South Korea
³Chao Family Comprehensive Cancer Center, University of California, Irvine, California, USA
⁴Center for Complex Biological Systems, University of California, Irvine, California, USA
⁵Center for Epigenetics and Metabolism, University of California, Irvine, California, USA

^∗These authors contributed equally to this article

Abstract

The consumption of fructose as sugar and high-fructose corn syrup has markedly increased during the past several decades. This trend coincides with the exponential rise of metabolic diseases, including obesity, nonalcoholic fatty liver disease, cardiovascular disease, and diabetes. While the biochemical pathways of fructose metabolism were elucidated in the early 1990s, organismal-level fructose metabolism and its whole-body pathophysiological impacts have been only recently investigated. In this review, we discuss the history of fructose consumption, biochemical and molecular pathways involved in fructose metabolism in different organs and gut microbiota, the role of fructose in the pathogenesis of metabolic diseases, and the remaining questions to treat such diseases.

논문정보

형식Review Paper
게재일2022년 08월 (BRIC 등록일 2022-08-25)
연구진국내+국외 연구진
분야 생명과학 > 생화학

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