한빛사논문
- 조회449
Yeon Jin Kim1, Beth B. Peterson1, Joanna D. Crook1, Hannah R. Joo1, Jiajia Wu2, Christian Puller1, Farrel R. Robinson1,3, Paul D. Gamlin4, King-Wai Yau5, Felix Viana6, John B. Troy2, Robert G. Smith7, Orin S. Packer1, Peter B. Detwiler8 & Dennis M. Dacey1,3,*
1Department of Biological Structure, University of Washington, Seattle, WA 98195, USA. 2Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA. 3Washington National Primate Research Center, Seattle, WA 98195, USA. 4Department of Ophthalmology and Vision Sciences, University of Alabama at Birmingham, Birmingham, AL 35294-4390, USA. 5Departments of Neuroscience and Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2185, USA. 6Institute of Neuroscience, UMH-CSIC, San Juan de Alicante 03550, Spain. 7Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA. 8Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA.
*Corresponding author.
Abstract
From mouse to primate, there is a striking discontinuity in our current understanding of the neural coding of motion direction. In non-primate mammals, directionally selective cell types and circuits are a signature feature of the retina, situated at the earliest stage of the visual process. In primates, by contrast, direction selectivity is a hallmark of motion processing areas in visual cortex, but has not been found in the retina, despite significant effort. Here we combined functional recordings of light-evoked responses and connectomic reconstruction to identify diverse direction-selective cell types in the macaque monkey retina with distinctive physiological properties and synaptic motifs. This circuitry includes an ON-OFF ganglion cell type, a spiking, ON-OFF polyaxonal amacrine cell and the starburst amacrine cell, all of which show direction selectivity. Moreover, we discovered that macaque starburst cells possess a strong, non-GABAergic, antagonistic surround mediated by input from excitatory bipolar cells that is critical for the generation of radial motion sensitivity in these cells. Our findings open a door to investigation of a precortical circuitry that computes motion direction in the primate visual system.
논문정보
- Research article
- 2022년 05월 (BRIC 등록일 2022-08-18)
- 국외 연구진
- 생명과학 > 세포생물학
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