한빛사논문
- 조회728
Min Beom Kim a, Soonho Hwangbo b,c, Sungho Jang d,e,f, Yun Kee Jo a,g,*
a Department of Biomedical Convergence Science and Technology, School of Convergence, Kyungpook National University, Daegu 41566, South Korea
b Department of Chemical Engineering, Gyeongsang National University, Jinju 52828, South Korea
c Department of Materials Engineering and Convergence Technology, Gyeongsang National University, Jinju 52828, South Korea
d Division of Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, South Korea
e Department of Bioengineering and Nano-Bioengineering, Incheon National University, Incheon 22012, South Korea
f Research Center for Bio Materials & Process Development, Incheon National University, Incheon 22012, South Korea
g Cell and Matrix Research Institute, Kyungpook National University, Daegu 41944, South Korea
* Corresponding author.
Abstract
The recent spike in the instances of complex physiological host-microbe interactions has raised the demand for developing in vitro models that recapitulate the microbial microenvironment in the human body. Organoids are steadily emerging as an in vitro culture system that closely mimics the structural, functional, and genetic features of complex human organs, particularly for better understanding host-microbe interactions. Recent advances in organoid culture technology have become new avenues for assessing the pathogenesis of symbiotic interactions, pathogen-induced infectious diseases, and various other diseases. The co-cultures of organoids with microbes have shown great promise in simulating host-microbe interactions with a high level of complexity for further advancement in related fields. In this review, we provide an overview of bioengineering approaches for microbe-co-cultured organoids. Latest developments in the applications of microbe-co-cultured organoids to study human physiology and pathophysiology are also highlighted. Further, an outlook on future research on bioengineered organoid co-cultures for various applications is presented.
논문정보
- Review Paper
- 2022년 07월 (BRIC 등록일 2022-08-12)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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