윤세현 (Northwestern University) | 한빛사논문 > 한빛사

한빛사논문

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Northwestern University

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Exp. Mol. Med., Published 06 July 2022 | https://doi.org/10.1038/s12276-022-00798-w Roles and mechanisms of ankyrin-G in neuropsychiatric disorders

Sehyoun Yoon¹, Nicolas H. Piguel¹ and Peter Penzes^1,2,3,*

¹Department of Neuroscience, Northwestern University, Chicago, IL 60611, USA. ²Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL 60611, USA. ³Northwestern University, Center for Autism and Neurodevelopment, Chicago, IL 60611, USA.

^*Corresponding author.

Abstract

Ankyrin proteins act as molecular scaffolds and play an essential role in regulating cellular functions. Recent evidence has implicated the ANK3 gene, encoding ankyrin-G, in bipolar disorder (BD), schizophrenia (SZ), and autism spectrum disorder (ASD). Within neurons, ankyrin-G plays an important role in localizing proteins to the axon initial segment and nodes of Ranvier or to the dendritic shaft and spines. In this review, we describe the expression patterns of ankyrin-G isoforms, which vary according to the stage of brain development, and consider their functional differences. Furthermore, we discuss how posttranslational modifications of ankyrin-G affect its protein expression, interactions, and subcellular localization. Understanding these mechanisms leads us to elucidate potential pathways of pathogenesis in neurodevelopmental and psychiatric disorders, including BD, SZ, and ASD, which are caused by rare pathogenic mutations or changes in the expression levels of ankyrin-G in the brain.

논문정보

형식Review Paper
게재일2022년 07월 (BRIC 등록일 2022-08-12)
연구진국외 연구진
분야 생명과학 > 신경생물학

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