한빛사논문
- 조회572
Keya Ganguly a,1, Hexiu Jin d,1, Sayan Deb Dutta a,1, Dinesh K. Patel c, Tejal V. Patil a,b, KiTaek Lim a,b,*
a Department of Biosystems Engineering, Kangwon National University, Chuncheon 24341, Republic of Korea b Interdisciplinary Program in Smart Agriculture, Kangwon National University, Chuncheon 24341, Republic of Korea c Institute of Forest Science, Kangwon National University, Chuncheon 24341, Republic of Korea d Department of Plastic and Traumatic Surgery, Capital Medical University, Beijing 10069, China
* Corresponding author.
1 Contributed equally
Abstract
This study was focused on utilizing the magneto-responsiveness of cellulose nanocrystals (CNCs) in an alginate-silk fibroin (ASF) matrix under a low-strength (0.28 T) magnetic field (MF) for fabrication of a magnetically aligned, anisotropic, three-dimensional wound healing scaffold. The effect of the MF on three different concentrations of CNCs (0.5%, 1%, and 2%) was studied to control the alignment of the ASF scaffold. The as-fabricated scaffolds exhibited a concentration-dependent anisotropy with respect to the CNCs. The SEM, AFM, and, SAXS analysis indicated a higher degree of anisotropy of the MF-treated scaffolds with significant enhancement of Young's modulus vis-à-vis control, demonstrating their mechanical stability. Skin fibroblasts, keratinocytes, and endothelial cells cultured on the magnetically aligned scaffolds showed enhanced proliferation in vitro and demonstrated rapid wound closure under in vivo conditions. Hence, the magnetic property of CNCs could be useful for developing biomimetic anisotropic constructs for wound healing applications.
논문정보
- Research article
- 2022년 07월 (BRIC 등록일 2022-08-10)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 의료기기
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