한빛사논문
- 조회741
Xiaoping Wu1, Yunju Jeong2,3, Sergio Poli de Frías4, Imaani Easthausen5, Katherine Hoffman5, Clara Oromendia5, Shahrad Taheri6, J Esposito2,7, Luisa Quesada Arias4, Ehab A Ayaub2, Rie Maurer8, Ritu R Gill9, Hiroto Hatabu3,10, Mizuki Nishino3,10, Michelle L Frits11, Christine K Iannaccone11, Michael E Weinblatt3,11, Nancy A Shadick3,11, Paul F Dellaripa3,11, Augustine M K Choi1, Edy Y Kim2,3, Ivan O Rosas12, Fernando J Martinez1, J Doyle2,3
1Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, New York, USA
2Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA
3Harvard Medical School, Boston, Massachusetts, USA
4Department of Medicine, Mount Sinai Medical Center, Miami Beach, Florida, USA
5Department of Population Health Science, Division of Biostatistics, Weill Cornell Medicine, New York, New York, USA
6Department of Medicine, Weill Cornell Medicine–Qatar, Ar-Rayyan, Qatar
7Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
8Center for Clinical Investigation, Brigham and Women's Hospital, Boston, Massachusetts, USA
9Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
10Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA
11Department of Medicine, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, Massachusetts, USA
12Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, Texas, USA
XW and YJ contributed equally.
Correspondence to Dr Tracy J Doyle
Abstract
Although interstitial lung disease (ILD) causes significant morbidity and mortality in rheumatoid arthritis (RA), it is difficult to predict the development or progression of ILD, emphasising the need for improved discovery through minimally invasive diagnostic tests. Aptamer-based proteomic profiling was used to assess 1321 proteins from 159 patients with rheumatoid arthritis with interstitial lung disease (RA-ILD), RA without ILD, idiopathic pulmonary fibrosis and healthy controls. Differential expression and gene set enrichment analyses revealed molecular signatures that are strongly associated with the presence and severity of RA-ILD and provided insight into unexplored pathways of disease. These warrant further study as non-invasive diagnostic tools and future therapeutic targets.
논문정보
- Research article
- 2022년 07월 (BRIC 등록일 2022-08-08)
- 국외 연구진
- 의약학 > 응용의학
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