한빛사논문
- 조회353
Jeong-Yun Lee,1,5,* Taeyi You,1,2,3,5 Choong-Hee Lee,1 Geun Ho Im,1 Heewon Seo,1,4 Choong-Wan Woo,1,2,3 and Seong-Gi Kim1,2,3,6,*
1Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon 16419, Republic of Korea
2Department of Biomedical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea
3Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea
4Department of Chemistry and Biochemistry, Oberlin College, Oberlin, OH 44704, USA
5These authors contributed equally.
6Lead contact
*Correspondence
Abstract
Although pain-related excessive fear is known to be a key factor in chronic pain disability, which involves the anterior cingulate cortex (ACC), little is known about the downstream circuits of the ACC for fear avoidance in pain processing. Using behavioral experiments and functional magnetic resonance imaging with optogenetics at 15.2 T, we demonstrate that the ACC is a part of the abnormal circuit changes in chronic pain and its downstream circuits are closely related to modulating sensorimotor integration and generating active movement rather than carrying sensory information. The projection from the ACC to the dorsolateral and lateral parts of the periaqueductal gray (dl/lPAG) especially enhances both reflexive and active avoidance behavior toward pain. Collectively, our results indicate that increased signals from the ACC to the dl/lPAG might be critical for excessive fear avoidance in chronic pain disability.
논문정보
- Research article
- 2022년 05월 (BRIC 등록일 2022-07-14)
- 국내(교신)+국외 연구진
- 생명과학 > 생리학
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