김진 (서울대학교 수의과대학, 건국대학교 수의과대학)

한빛사논문

조회638

서울대학교 수의과대학, 건국대학교 수의과대학

CV File 189 kb

Sci. Adv., 2022 Jun 10;8(23):eabo3209 | https://doi.org/10.1126/sciadv.abo3209 Digital selective transformation and patterning of highly conductive hydrogel bioelectronics by laser-induced phase separation

Daeyeon Won^1,2†, Jin Kim^3,4†, Joonhwa Choi^1,2, HyeongJun Kim⁵, Seonggeun Han^1,2, Inho Ha^1,2, Junhyuk Bang^1,2, Kyun Kyu Kim^1,2, Youngseok Lee^1,2, Taek-Soo Kim⁵, Jae-Hak Park³, C-Yoon Kim^4*, Seung Hwan Ko^1,2,6*

¹Soft Robotics Research Center, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. ²Applied Nano and Thermal Science Lab, Department of Mechanical Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. ³Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, 1, Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. ⁴College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea. ⁵Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea. ⁶Institute of Advanced Machines and Design/Institute of Engineering Research, Seoul National University, Seoul 08826, Republic of Korea.

^*Corresponding author.
^†These authors contributed equally to this work.

Abstract

The patterning of poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) hydrogels with excellent electrical property and spatial resolution is a challenge for bioelectronic applications. However, most PEDOT:PSS hydrogels are fabricated by conventional manufacturing processes such as photolithography, inkjet printing, and screen printing with complex fabrication steps or low spatial resolution. Moreover, the additives used for fabricating PEDOT:PSS hydrogels are mostly cytotoxic, thus requiring days of detoxification. Here, we developed a previously unexplored ultrafast and biocompatible digital patterning process for PEDOT:PSS hydrogel via phase separation induced by a laser. We enhanced the electrical properties and aqueous stability of PEDOT:PSS by selective laser scanning, which allowed the transformation of PEDOT:PSS into water-stable hydrogels. PEDOT:PSS hydrogels showed high electrical conductivity of 670 S/cm with 6-μm resolution in water. Furthermore, electrochemical properties were maintained even after 6 months in a physiological environment. We further demonstrated stable neural signal recording and stimulation with hydrogel electrodes fabricated by laser.

논문정보

형식Research article
게재일2022년 06월 (BRIC 등록일 2022-07-06)
연구진국내 연구진
분야 의약학 > 재생의학

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