한빛사논문
- 조회592
Chung-Sung Lee,*,a,b,c,#, Jiabing Fan,a,#, Hee Sook Hwang,d,#, Chen Chen,a, Soyon Kim,a, Tara Aghaloo,e, and Min Lee,*,a,f
a Division of Advanced Prosthodontics, University of California, Los Angeles, California 90095, United States
b Department of Pharmaceutical Engineering and Biotechnology, Sun Moon University, Asan 31460, Republic of Korea
c Genome-based BioIT Convergence Institute, Asan 31460, Republic of Korea
d Department of Pharmaceutical Engineering, Dankook University, Cheonan 31116, Republic of Korea
e Division of Diagnostic and Surgical Sciences, School of Dentistry, University of California, Los Angeles, California 90095, United States
f Department of Bioengineering, University of California, Los Angeles, California 90095, United States
# C.-S.L., J.F., and H.S.H. contributed equally to this work.
* Corresponding author:
Abstract
Despite three-dimensional biomaterial scaffolds emerging for facilitating tissue remodeling and recovery in tissue engineering, the scaffolds with an insufficient oxygen supply are limited by various concerns, such as their retention, localization, survival, and lineage fate control of post-transplantation of stem cells. Herein, we report oxygen-enriched osteoinductive nanoerythrocytes as a facile biomimetic platform for bone formation, combining the biocompatibility of natural red blood cell membranes with the oxygen-carrying perfluorocarbons and the osteoinductive oxysterols. The resulting nanoerythrocytes exhibit a high capacity for oxygen delivery, improving cell survival and proliferation and mitigating hypoxic stress in cell-laden hydrogels as a three-dimensional biomaterial device in vitro and in vivo. Notably, the introduction of oxysterols incites the osteoinductive activity for the differentiation of progenitor cells toward osteogenic lineage through the positive regulation of Hedgehog signaling and in vivo reossification activity against a nonhealing calvarial defect. Given the beneficial properties of the assembled parts in a facile single system, this bioactive and biomimetic nanodelivery system can have the potential to address desired needs in the biomaterial scaffolds for cell delivery and bone tissue engineering.
논문정보
- Research article
- 2022년 06월 (BRIC 등록일 2022-06-30)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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