한빛사논문
- 조회1,053
Hyungyou Park1,6, Minah Kim2,3,6, Yoo Bin Kwak1, Kang Ik K. Cho4, Junhee Lee5, Sun-Young Moon2,3, Silvia Kyungjin Lho2,3 and Jun Soo Kwon1,2,3,5,*
1Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea. 2Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea. 3Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea. 4Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA. 5Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea. 6These authors contributed equally: Hyungyou Park, Minah Kim.
*Corresponding author.
Abstract
The striatum and its cortical circuits play central roles in the pathophysiology of obsessive-compulsive disorder (OCD). The striatum is subdivided by cortical connections and functions; however, the anatomical aberrations in different cortico-striatal connections and coexisting microstructural anomalies in striatal subregions of OCD patients are poorly understood. Thus, we aimed to elucidate the aberrations in cortico-striatal white matter (WM) connectivity and the associated subregional microstructure of the striatum in patients with OCD. From diffusion tensor/kurtosis imaging of 107 unmedicated OCD patients and 110 matched healthy controls (HCs), we calculated the cortico-striatal WM connectivity and segmented the striatum using probabilistic tractography. For the segmented striatal subregions, we measured average diffusion kurtosis values, which represent microstructural complexity. Connectivity and mean kurtosis values in each cortical target and associated striatal subregions were compared between groups. We identified significantly reduced orbitofrontal WM connectivity with its associated striatal subregion in patients with OCD compared to that in HCs. However, OCD patients exhibited significantly increased caudal-motor and parietal connectivity with the associated striatal subregions. The mean kurtosis values of the striatal subregions connected to the caudal-motor and parietal cortex were significantly decreased in OCD patients. Our results highlighted contrasting patterns of striatal WM connections with the orbitofrontal and caudal-motor/parietal cortices, thus supporting the cortico-striatal circuitry imbalance model of OCD. We suggest that aberrations in WM connections and the microstructure of their downstream regions in the caudal-motor-/parietal-striatal circuits may underlie OCD pathophysiology and further provide potential neuromodulation targets for the treatment of OCD.
논문정보
- Research article
- 2022년 05월 (BRIC 등록일 2022-06-22)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 뇌인지과학
관련 웨비나
![선조체 회로로 보는 강박증의 뇌구조 [Mol. Psychiatr.]](/upload/board/files/onseminar/thumb/thumb_0000420.png)
학술웨비나
선조체 회로로 보는 강박증의 뇌구조 [Mol. Psychiatr.] 강박증은 본인의 의지와 상관없이 특정 생각, 충동, 장면(강박사고)이 끊임없이 떠오르고 이에 따른 불안을 해소하기 위해 특정 행동(강박행동)을 반복하는 정신질환이다. 이러한 강박증의 핵심 뇌 기전으로는 피질-선조체 회로(cortico-striatal circuit)가 꼽힌다. 선조체는 대뇌 피질로부터 정보를 받아 보상이나, 집행, 자기 조절과 운동 능력 등에 관여하는 중요한 뇌 영역이다. 특히 대뇌피질과 선조체가 이루는 신경 회로의 기능 이상은 강박증의 원인으로 제기되어 왔다. 하지만 이러한 회로 기저에 있는 백질 구조에 대한 이해는 부족했다. 이번 세미나에서는 MRI 확산 텐서 영상(diffusion tensor imaging, DTI)을 이용해 피질-선조체 회로의 백질 구조를 구현하고, 확산 첨도 영상(diffusion kurtosis imaging, DKI)를 이용해 선조체의 미세구조까지 관찰한 일련의 과정과 그 결과를 소개한다. (Park et al. Mol Psychiatry. 2022)- 박현규(서울대학교)
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