한빛사논문
- 조회384
Jun-Hyeok Han, Ha Eun Shin, Jiyoung Lee, Jeon Min Kang, Jung-Hoon Park, Chun Gwon Park, Dong Keun Han,* Ik-Hwan Kim,* and Wooram Park*
J.-H. Han, H. E. Shin, W. Park
Department of Integrative Biotechnology College of Biotechnology and Bioengineering Sungkyunkwan University Seoburo 2066, Suwon, Gyeonggi 16419, Republic of Korea
J.-H. Han, I.-H. Kim
Department of Biotechnology College of Life Sciences and Biotechnology Korea University Seoul 02841, Republic of Korea
J. Lee
Institute of Pharmaceutics College of Pharmaceutical Sciences Zhejiang University Hangzhou, Zhejiang 310058, People’s Republic of China
J. M. Kang, J.-H. Park
Biomedical Engineering Research Center Asan Institute for Life Sciences Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea
C. G. Park
Department of Biomedical Engineering SKKU Institute for Convergence Sungkyunkwan University Suwon, Gyeonggi 16419, Republic of Korea
C. G. Park
Department of Intelligent Precision Healthcare Convergence SKKU Institute for Convergence Sungkyunkwan University Suwon, Gyeonggi 16419, Republic of Korea
D. K. Han
Department of Biomedical Science College of Life Sciences CHA University 335 Pangyo-ro, Bundang-gu, Seongnam, Gyeonggi 13488, Republic of Korea
J.-H.H. and H.E.S. contributed equally to this work.
*Corresponding author.
Abstract
To circumvent the limitations of conventional cancer immunotherapy, it is critical to prime antigen-presenting cells (APCs) to initiate the cancer-immune cycle. Here, the authors develop a metal-phenolic network (MPN)-based immunoactive nanoparticle in combination with irreversible electroporation (IRE) for an effective cancer immunotherapy. The MPN nanoparticles are synthesized by coordinating tannic acid with manganese (Mn) ions, and subsequent coating with CpG-oligodeoxynucleotides (CpG-ODNs) via hydrogen bonding. The CpG-ODN-coated Mn-phenolic network (CMP) nanoparticles are effectively internalized into macrophages, a type of APCs, and successfully trigger M1 polarization to promote release of proinflammatory cytokines. Notably, the CMP nanoparticles demonstrate an extended retention time period than the free CpG-ODN in the tumor. The tumor microenvironment tailored bipolar IRE, enhances the therapeutic efficacy by significantly broadening the ablation zone, which further increases immunogenic cell death (ICD). Ultimately, the simultaneous CMP nanoparticles and IRE treatment successfully inhibit tumor growth and prolong survival in a mouse tumor model. Thus, CMP nanoparticles are empowered with Mn and CpG-ODN immunomodulators and the tumor microenvironment tailored bipolar IRE will be a new tool for effective cancer immunotherapy to treat intractable malignancies.
논문정보
- Research article
- 2022년 05월 (BRIC 등록일 2022-06-15)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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