한빛사논문
- 조회542
Mihály Vöröslakos, Kanghwan Kim, Nathan Slager, Eunah Ko, Sungjin Oh, Saman S. Parizi, Blake Hendrix, John P. Seymour, Kensall D. Wise, György Buzsáki,* Antonio Fernández-Ruiz,* and Euisik Yoon*
M. Vöröslakos, K. Kim, N. Slager, E. Ko, S. Oh, S. S. Parizi, B. Hendrix, J. P. Seymour, K. D. Wise, E. Yoon
Department of Electrical Engineering and Computer Science University of Michigan Ann Arbor, MI 48109, USA
M. Vöröslakos, G. Buzsáki
Neuroscience Institute Langone Medical Center New York University New York, NY 10016, USA
K. Kim
Center for BioMicrosystems Brain Science Institute Korea Institute of Science and Technology Seoul 02792, South Korea
J. P. Seymour
Department of Neurosurgery University of Texas Health Science Center Houston, TX 77030, USA
A. Fernández-Ruiz
Department of Neurobiology and Behavior Cornell University Ithaca, NY 14853, USA
E. Yoon
Department of Biomedical Engineering University of Michigan Ann Arbor, MI 48109, USA
E. Yoon
Center for Nanomedicine Institute for Basic Science (IBS) and Graduate Program of Nano Biomedical Engineering (Nano BME) Advanced Science Institute Yonsei University Seoul 03722, South Korea
M.V. and K.K. contributed equally to this work.
*Corresponding author.
Abstract
Dynamic interactions within and across brain areas underlie behavioral and cognitive functions. To understand the basis of these processes, the activities of distributed local circuits inside the brain of a behaving animal must be synchronously recorded while the inputs to these circuits are precisely manipulated. Even though recent technological advances have enabled such large-scale recording capabilities, the development of the high-spatiotemporal-resolution and large-scale modulation techniques to accompany those recordings has lagged. A novel neural probe is presented in this work that enables simultaneous electrical monitoring and optogenetic manipulation of deep neuronal circuits at large scales with a high spatiotemporal resolution. The “hectoSTAR” micro-light-emitting-diode (μLED) optoelectrode features 256 recording electrodes and 128 stimulation μLEDs monolithically integrated on the surface of its four 30-µm thick silicon micro-needle shanks, covering a large volume with 1.3-mm × 0.9-mm cross-sectional area located as deep as 6 mm inside the brain. The use of this device in behaving mice for dissecting long-distance network interactions across cortical layers and hippocampal regions is demonstrated. The recording-and-stimulation capabilities hectoSTAR μLED optoelectrodes enables will open up new possibilities for the cellular and circuit-based investigation of brain functions in behaving animals.
논문정보
- Research article
- 2022년 04월 (BRIC 등록일 2022-07-01)
- 국내(교신)+국외 연구진
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