한빛사논문
Youngrong Park, Ananiya A. Demessie, Addie Luo, Olena R. Taratula, Abraham S. Moses, Peter Do, Leonardo Campos, Younes Jahangiri, Cory R. Wyatt, Hassan A. Albarqi, Khashayar Farsad, Ov D. Slayden,* and Oleh Taratula*
Y. Park, A. A. Demessie, O. R. Taratula, A. S. Moses, P. Do, O. Taratula
College of Pharmacy Oregon State University 2730 S Moody Avenue, Portland, Oregon 97201, USA
A. Luo, O. D. Slayden
Division of Reproductive and Developmental Sciences Oregon National Primate Research Center Oregon Health and Science University 505 NW 185th Avenue Beaverton, Portland, Oregon 97006, USA
L. Campos, Y. Jahangiri, K. Farsad
Dotter Interventional Institute Department of Interventional Radiology Oregon Health and Science University 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
C. R. Wyatt
Department of Diagnostic Radiology Oregon Health and Sciences University 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
C. R. Wyatt
Advanced Imaging Research Center Oregon Health and Sciences University 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
H. A. Albarqi
Department of Pharmaceutics College of Pharmacy Najran University King Abdulaziz Road, Najran 55461, Saudi Arabia
*Corresponding author.
Abstract
Endometriosis is a devastating disease in which endometrial-like tissue forms lesions outside the uterus. It causes infertility and severe pelvic pain in ≈176 million women worldwide, and there is currently no cure for this disease. Magnetic hyperthermia could potentially eliminate widespread endometriotic lesions but has not previously been considered for treatment because conventional magnetic nanoparticles have relatively low heating efficiency and can only provide ablation temperatures (>46 °C) following direct intralesional injection. This study is the first to describe nanoparticles that enable systemically delivered magnetic hyperthermia for endometriosis treatment. When subjected to an alternating magnetic field (AMF), these hexagonal iron-oxide nanoparticles exhibit extraordinary heating efficiency that is 6.4× greater than their spherical counterparts. Modifying nanoparticles with a peptide targeted to vascular endothelial growth factor receptor 2 (VEGFR-2) enhances their endometriosis specificity. Studies in mice bearing transplants of macaque endometriotic tissue reveal that, following intravenous injection at a low dose (3 mg per kg), these nanoparticles efficiently accumulate in endometriotic lesions, selectively elevate intralesional temperature above 50 °C upon exposure to external AMF, and completely eradicate them with a single treatment. These nanoparticles also demonstrate promising potential as magnetic resonance imaging (MRI) contrast agents for precise detection of endometriotic tissue before AMF application.
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