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조회1,102

차의과학대학교

Biochim. Biophys. Acta-Rev. Cancer, Volume 1877, Issue 3, May 2022, 188736 | https://doi.org/10.1016/j.bbcan.2022.188736 E3 ligases and deubiquitinating enzymes regulating the MAPK signaling pathway in cancers

Hong-Beom Park, Kwang-Hyun Baek*

Department of Biomedical Science, CHA University, Gyeonggi-Do 13488, Republic of Korea

*Corresponding author

Abstract

The mitogen-activated protein kinase (MAPK) signaling pathway is the primary regulatory module of various cellular processes such as cell proliferation, differentiation, and stress responses. This pathway converts external stimuli to cellular responses via three major kinases: mitogen-activated protein kinase (MAPK), mitogen-activated protein kinase kinase (MAPKK), and mitogen-activated protein kinase kinase kinase (MAPKKK). Ubiquitination is a post-translational modification of proteins with ubiquitin, which results in the formation of mono- or poly-ubiquitin chains of substrate proteins. Conversely, removal of the ubiquitin by deubiquitinating enzymes (DUBs) is known as deubiquitination. This review summarizes mechanisms of the MAPK signaling pathways (ERK1/2, ERK5, p38, and JNK1/2/3 signaling pathway) in cancers, and of E3 ligases and DUBs that target the MAPK signaling components such as Raf, MEK1/2, ERK1/2, MEKK2/3, MEKK1-4, TAK1, DLK1, MLK1-4, ASK1/2, and MKK3-7.

논문정보

형식Review Paper
게재일2022년 05월 (BRIC 등록일 2022-05-25)
연구진국내 연구진
분야 생명과학 > 노화/암생물학

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