명우재 (분당서울대학교병원, 서울대학교) | 한빛사논문 > 한빛사

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분당서울대학교병원, 서울대학교

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Nat. Hum. Behav., Published 19 May 2022 | https://doi.org/10.1038/s41562-022-01343-5 Shared genetic architectures of subjective well-being in East Asian and European ancestry populations

Soyeon Kim^a,b,c,d†, Kiwon Kime^†, Mi Yeong Hwangf^†, Hyunwoong Ko^g, Sang-Hyuk Jung^a, Injeong Shim^a, Soojin Cha^a, Hyewon Lee^h, Beomsu Kim^a, Joohyun Yoon^b, Tae Hyon Ha^b, Doh Kwan Kimⁱ, Jinho Kim^j, Woong-Yang Park^k, Aysu Okbay^l, Bong-Jo Kim^f, Young Jin Kim^f*, Woojae Myung^b*, Hong-Hee Won^a,k*

^a Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea
^b Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea
^c Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
^d Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
^e Department of Psychiatry, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea
^f Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbukdo, South Korea
^g Interdisciplinary Program in Cognitive Science, Seoul National University, Seoul, South Korea
^h Department of Health Administration and Management, College of Medical Sciences, Soonchunhyang University, Asan-si, Chungcheongnam-do, South Korea
ⁱDepartment of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
^j Precision Medicine Center, Future Innovation Research Division, Seoul National University Bundang Hospital, Seongnam, South Korea
^kSamsung Genome Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
^lDepartment of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

^†These authors contributed equally to this work.
^*These authors jointly supervised this work. Correspondence to Young Jin Kim, Woojae Myung, and Hong-Hee Won

Abstract

Subjective well-being (SWB) has been explored in European ancestral populations; however, whether the SWB genetic architecture is shared across populations remains unclear. We conducted a cross-population genome-wide association study for SWB using samples from Korean (n = 110,919) and European (n = 563,176) ancestries. Five ancestry-specific loci and twelve cross-ancestry significant genomic loci were identified. One novel locus (rs12298541 near HMGA2) associated with SWB was also identified through the European meta-analysis. Significant cross-ancestry genetic correlation for SWB between samples was observed. Polygenic risk analysis in an independent Korean cohort (n = 22,455) demonstrated transferability between populations. Significant correlations between SWB and major depressive disorder, and significant enrichment of central nervous system-related polymorphisms heritability in both ancestry populations were found. Hence, large-scale cross-ancestry genome-wide association studies can advance our understanding of SWB genetic architecture and mental health.

논문정보

형식Research article
게재일2022년 05월 (BRIC 등록일 2022-05-24)
연구진국내(교신)+국외 연구진
분야 의약학 > 유전 및 유전체의학

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