전형주 (한국과학기술연구원(KIST))

한빛사논문

조회899

한국과학기술연구원(KIST)

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Cell Reports, Volume 38, Issue 9, 1 March 2022, 110439 | https://doi.org/10.1016/j.celrep.2022.110439 Topographic connectivity and cellular profiling reveal detailed input pathways and functionally distinct cell types in the subthalamic nucleus

Hyungju Jeon,^1,6 Hojin Lee,^1,2,6 Dae-Hyuk Kwon,³ Jiwon Kim,^1,2 Keiko Tanaka-Yamamoto,^1,2 Jang Soo Yook,¹ Linqing Feng,¹ Hye Ran Park,⁴ Yong Hoon Lim,⁵ Zang-Hee Cho,³ Sun Ha Paek,⁵ and Jinhyun Kim^1,2,7,*

¹Brain Science Institute, Korea Institute of Science and Technology (KIST), 39-1 Hawolgokdong, Seongbukgu, Seoul 02792 Korea ²Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology, Seoul 02792, Korea ³Neuroscience Convergence Center, Korea University, Seoul 02841, Korea ⁴Soonchunhyang University Seoul Hospital, Seoul 04401, Korea ⁵Neurosurgery, Movement Disorder Center, Seoul National University College of Medicine, Advanced Institute of Convergence Technology (AICT), Seoul National University, Seoul 03080, Korea ⁶These authors contributed equally ⁷Lead contact

^*Correspondence

Abstract

The subthalamic nucleus (STN) controls psychomotor activity and is an efficient therapeutic deep brain stimulation target in individuals with Parkinson's disease. Despite evidence indicating position-dependent therapeutic effects and distinct functions within the STN, the input circuit and cellular profile in the STN remain largely unclear. Using neuroanatomical techniques, we construct a comprehensive connectivity map of the indirect and hyperdirect pathways in the mouse STN. Our circuit- and cellular-level connectivities reveal a topographically graded organization with three types of indirect and hyperdirect pathways (external globus pallidus only, STN only, and collateral). We confirm consistent pathways into the human STN by 7 T MRI-based tractography. We identify two functional types of topographically distinct glutamatergic STN neurons (parvalbumin [PV+/−]) with synaptic connectivity from indirect and hyperdirect pathways. Glutamatergic PV+ STN neurons contribute to burst firing. These data suggest a complex interplay of information integration within the basal ganglia underlying coordinated movement control and therapeutic effects.

논문정보

형식Research article
게재일2022년 03월 (BRIC 등록일 2022-05-11)
연구진국내 연구진
분야 생명과학 > 신경생물학

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