한빛사논문
- 조회732
Yi Guan, MS*, Seyed Amir Ebrahimzadeh, MD*, Chia-hsin Cheng, BS, Weifan Chen, MS, Tiffany Leung, Sherman Bigornia, PhD, Natalia Palacios, PhD, Mahdi O. Garelnabi, PhD, Tammy Scott, PhD, Rafeeque Bhadelia, MD, Katherine L. Tucker, PhD, Bang-Bon Koo, PhD; on behalf of the Alzheimer's Disease Neuroimaging Initiative
From the Department of Anatomy and Neurobiology (Y.G., C.-h.C., W.C., T.L., B.-B.K.), Boston University School of Medicine; Department of Radiology (S.A.E., R.B.), Neuroradiology Section, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Agriculture, Nutrition, and Food Systems (S.B.), College of Life Sciences and Agriculture, University of New Hampshire, Durham; Departments of Public Health (N.P., M.O.G.) and Biomedical and Nutritional Sciences (K.L.T.), Zuckerberg College of Health Sciences, and Center for Population Health (N.P., K.L.T.), University of Massachusetts Lowell; and School of Medicine (T.S.), Tufts University, Boston, MA.
Correspondence Dr. Koo
Abstract
Background and objectives: The Boston Puerto Rican Health Study (BPRHS) is a longitudinal study following self-identified Puerto Rican older adults living in the Greater Boston area. Studies have shown higher prevalence of hypertension (HTN) and type 2 diabetes (T2D) within this ethnic group compared to age-matched non-Hispanic White adults. In this study, we investigated the associations of HTN and T2D comorbidity on brain structural integrity and cognitive capacity in community-dwelling Puerto Rican adults and compared these measures with older adult participants (non-Hispanic White and Hispanic) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and National Alzheimer's Coordinating Center (NACC) databases.
Methods: BPRHS participants who underwent brain MRI and cognitive testing were divided into 4 groups based on their HTN and T2D status: HTN-/T2D-, HTN+/T2D-, HTN-/T2D+, and HTN+/T2D+. We assessed microstructural integrity of white matter (WM) pathways using diffusion MRI, brain macrostructural integrity using hippocampal volumes, and brain age using T1-weighted MRI and cognitive test scores. BPRHS results were then compared with results from non-Hispanic White and Hispanic participants from the ADNI and NACC databases.
Results: The prevalence of HTN was almost 2 times (66.7% vs 38.7%) and of T2D was 5 times (31.8% vs 6.6.%) higher in BPRHS than in ADNI non-Hispanic White participants. Diffusion MRI showed clear deterioration patterns in major WM tracts in the HTN+/T2D+ group and, to a lesser extent, in the HTN+/T2D- group compared to the HTN-/T2D- group. HTN+/T2D+ participants also had the smallest hippocampal volume and larger brain aging deviations. Trends toward lower executive function and global cognitive scores were observed in HTN+/T2D+ relative to HTN-/T2D- individuals. MRI measures and the Mini-Mental State Examination (MMSE) scores from the HTN+/T2D+ BPRHS group resembled those of ADNI White participants with progressive mild cognitive impairment (MCI), while the BPRHS HTN-/T2D- participants resembled participants with stable MCI. The BPRHS was not significantly different from the ADNI + NACC Hispanic cohort on imaging or MMSE measures.
Discussion: The effects of T2D and HTN comorbidity led to greater brain structural disruptions than HTN alone. The high prevalence of HTN and T2D in the Puerto Rican population may be a key factor contributing to health disparities in cognitive impairment in this group compared to non-Hispanic White adults in the same age range.
논문정보
- Research article
- 2022년 04월 (BRIC 등록일 2022-04-13)
- 국외 연구진
- 바이오·의료융합 > 뇌인지과학
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