한빛사논문
- 조회366
Cho Rim Kim1, Yong Chan Cho1, Seung Ho Lee2, Jae Hoon Han1, Min Ji Kim1, Han Bi Ji1, Se-Na Kim2, Chang Hee Min2, Byung Ho Shin3, Cheol Lee4, Young Min Cho5,6, Young Bin Choy1,2,3
1Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, South Korea 2Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul, South Korea 3Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, South Korea 4Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea 5Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea 6Department of Translational Medicine, College of Medicine, Seoul National University, Seoul, South Korea
Cho Rim Kim, Yong Chan Cho, and Seung Ho Lee contributed equally to this study as first authors.
Correspondence Young Bin Choy
Abstract
Self-injectable therapy has several advantages in the treatment of metabolic disorders. However, frequent injections with needles impair patient compliance and medication adherence. Therefore, we develop a fully implantable device capable of on-demand administration of self-injection drugs via noninvasive manual button clicks on the outer skin. The device is designed to infuse the drug only at the moment of click actuation, which allows for an accurate and reproducible drug infusion, and also prevents unwanted drug leakage. Using a mechanical means of drug infusion, this implantable device does not contain any electronic compartments or batteries, making it compact, and semi-permanent. When tested in animals, the device can achieve subcutaneous injection-like pharmacokinetic and pharmacodynamic effects for self-injection drugs such as exenatide, insulin, and glucagon.
논문정보
- Research article
- 2022년 03월 (BRIC 등록일 2022-04-13)
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