한빛사논문
- 조회799
Bohwa Hana,1, Yeonju Songa,1, Jeehun Parkb,*, Junsang Doha,b,c,*
aDepartment of Materials Science and Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea bResearch Institute of Advanced Materials (RIAM), Institute of Engineering Research, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea cInstitute of Engineering Research, Bio-MAX Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea
*Corresponding authors.
1These authors contributed equally to the work.
Abstract
Recent clinical successes of chimeric antigen receptor (CAR) T cell therapy have led the booming of developments in cancer immunotherapy utilizing ex vivo engineered immune cells such as T cells and natural killer (NK) cells. However, a number of issues need to be resolved for this novel therapy to become widely applicable to cancer patients as current CAR-T cell therapies are only successful in treating some blood cancers, and economically not feasible for many patients. In this review, we describe various nanomaterial-based approaches developed to overcome current limitations in ex vivo engineered T/NK cells, along with key biological principles underlying each approach. First, nanomaterials developed to improve ex vivo expansion of T/NK cells and the basic principles of T/NK cell activation for designing nanomaterials are summarized. Second, nanomaterial-based gene delivery methods to generate genetically engineered T/NK cells are discussed with an emphasis on challenges in improving transfection efficacy. Third, nanomaterials loaded to T/NK cells to enhance their anti-tumor functions and to overcome tumor microenvironment are described with key biological characteristics of T/NK cells, which are essential for nanomaterial loading and drug release from the nanomaterials. In particular, we comment on similarities and differences of methods developed for T cells and NK cells based on the biological characteristics of each cell type.
논문정보
- Research article
- 2022년 03월 (BRIC 등록일 2022-03-29)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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